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Three-Dimensional Radiopharmaceutical-Excited Fluorescence Imaging of Lymph Nodes

  • Northwest University China
  • CAS - Institute of Automation

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

Optical imaging techniques have been developed for localizing lymph nodes before surgical resection due to the non-invasion and high sensitivity. However, its attendant penetrability limitations and auto-fluorescence effect have greatly limited the spatial resolution and imaging precision. In this study, a novel technique radiopharmaceutical-excited fluorescence imaging (REFI) was adopted to image lymph nodes, which use gamma-ray and Cerenkov radiation from radioisotopes to excite lanthanide europium oxide (EO) nanophosphors and boost the light intensity. An effective adaptive-steepest-descent-projection onto convex sets (ASD-POCS) reconstruction algorithm and the anatomic structure information were used to three-dimensionally image lymph nodes in mice models. The results indicate that REFI can greatly boost the light intensity and accuracy of threedimensional imaging of lymph node with location deviation less than 1.03 mm.

源语言英语
主期刊名2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
出版商Institute of Electrical and Electronics Engineers Inc.
ISBN(电子版)9781538622827
DOI
出版状态已出版 - 12 11月 2018
已对外发布
活动2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Atlanta, 美国
期限: 21 10月 201728 10月 2017

出版系列

姓名2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings

会议

会议2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017
国家/地区美国
Atlanta
时期21/10/1728/10/17

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