The Detonation Wave Ignition (DWI) technique practiced its adaptation to the large liquid rocket engines which have multiple chambers or a large chamber with multiple combustion regions. It is an important step to describe the characteristics of DWI technique for engineering application. Theoretical analysis has been made in order to obtain the rule of mixture ratio influencing on detonation characteristics of GH2/GO2. Assumed that the detonation species were in chemical equilibrium on the C-J detonation wave surface, chemical equilibrium constant method was used to calculate the detonation species, and the thermodynamic parameters and the characteristic parameters of detonation wave were gained. Experimental system has been set up and more than 70 experiments have been carried out under different mixture condition. The pressure and the temperature of detonation wave have been obtained and the average velocity of detonation propagation between the test locations has been calculated. The influence of mixture ratio on detonation wave propagation velocity and detonation wave propagation Mach number has been studied and compared with each other under different mass flow rate condition. The theoretical results agree well with the experimental results.