TY - GEN
T1 - The mutual information of attractors in scale-free boolean networks
AU - Mi, Zhilong
AU - Guo, Binghui
AU - Zheng, Zhiming
N1 - Publisher Copyright:
© 2017 ACM.
PY - 2017/9/8
Y1 - 2017/9/8
N2 - Boolean Network, originally developed by Kauffman in 1969, is one of the models to study genetic regulatory networks, and it has been widely applied in Bioscience. In this paper, we proposed a model of Boolean Networks in which the topological structures and updating functions were different from the classical random graph model. For topological structures, the output degree of a node obeyed power law distribution, while the input of each node remained fixed as the classical N-K model. For updating functions, two parameters '1 and '2 were used to generate various Boolean functions. By calculating the mutual information and robustness of attractors in instances of Scale-free Boolean Networks, we investigated the relationships between structure parameters and rule parameters, which were involved in different phase with respect to different parameters. Furthermore, we observed that the structure parameters determined the regions that robustness '... and mutual information belonged to, while rule parameters 1 and '2 determined the relative values of R and L.
AB - Boolean Network, originally developed by Kauffman in 1969, is one of the models to study genetic regulatory networks, and it has been widely applied in Bioscience. In this paper, we proposed a model of Boolean Networks in which the topological structures and updating functions were different from the classical random graph model. For topological structures, the output degree of a node obeyed power law distribution, while the input of each node remained fixed as the classical N-K model. For updating functions, two parameters '1 and '2 were used to generate various Boolean functions. By calculating the mutual information and robustness of attractors in instances of Scale-free Boolean Networks, we investigated the relationships between structure parameters and rule parameters, which were involved in different phase with respect to different parameters. Furthermore, we observed that the structure parameters determined the regions that robustness '... and mutual information belonged to, while rule parameters 1 and '2 determined the relative values of R and L.
KW - Attractors
KW - Boolean networks
KW - Mutual information
UR - https://www.scopus.com/pages/publications/85041444341
U2 - 10.1145/3135954.3135963
DO - 10.1145/3135954.3135963
M3 - 会议稿件
AN - SCOPUS:85041444341
T3 - ACM International Conference Proceeding Series
SP - 36
EP - 39
BT - ICBCI 2017 - Proceedings of 2017 International Conference on Bioinformatics and Computational Intelligence
PB - Association for Computing Machinery
T2 - 2017 International Conference on Bioinformatics and Computational Intelligence, ICBCI 2017
Y2 - 8 September 2017 through 11 September 2017
ER -