The interface between probe and skin in non-invasive glucose sensing

Non-invasive blood glucose sensing often employs contact measurement, that is, the optical probe directly contacts the skin to reduce specular reflection. The contact pressure and the variation of skin temperature therefore contribute much to interference incurred by the internal structure and composition change of the detecting part. In this paper, we are going to discuss the influence of contact pressure between fiberoptic probe and skin as well as heat transfer on spectral measurement. A thorough investigation is made on approaches to eliminate these factors for both contact and non-contact measurement.