Surface Enhanced Raman Scattering substrates based on Au-molecularly imprinted nanofibers for phthalate esters detection

Phthalate esters (PAEs), a type of plasticizer extensively used in plastic products, are known as endocrine disruptors that exert various adverse physiological effects on organisms. Surface Enhanced Raman Scattering (SERS) technology offers effective detection of substances at low concentrations. However, its low sensitivity and poor specificity often lead to suboptimal outcomes in PAEs detection. Therefore, integrating molecular imprinting technology, nanomaterials, and SERS detection technology, an Au-molecularly imprinted nanofiber-enhanced substrate film was developed for PAEs detection. The addition of Au nanoparticles enhanced the Raman signal intensity of the SERS film. Molecularly imprinted nanofibers improved the adsorption capacity and specificity recognition of PAEs molecules. The optimal preparation method was investigated based on response surface analysis. Experimental results demonstrated that the lowest detectable concentration of PAEs was 10⁻⁸ mol/L. Thus, the Au-molecularly imprinted nanofiber-enhanced SERS substrate film represented a rapid, highly sensitive, and specific approach for PAEs detection.