TY - JOUR
T1 - Structural changes in brain regions involved in executive-control and self-referential processing after sleeve gastrectomy in obese patients
AU - Liu, Li
AU - Ji, Gang
AU - Li, Guanya
AU - Hu, Yang
AU - Jin, Qingchao
AU - Hu, Chunxin
AU - Zhao, Jizheng
AU - Meng, Qianqian
AU - von Deneen, Karen M.
AU - Chen, Antao
AU - Cui, Guangbin
AU - Wang, Huaning
AU - Zhao, Qingchuan
AU - Wu, Kaichun
AU - Tian, Jie
AU - Shokri-Kojori, Ehsan
AU - Tomasi, Dardo
AU - Volkow, Nora D.
AU - Nie, Yongzhan
AU - Zhang, Yi
AU - Wang, Gene Jack
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Obesity-related brain gray (GM) and white matter (WM) abnormalities have been reported in regions associated with food-intake control and cognitive-emotional regulation. Bariatric surgery (BS) is the most effective way to treat obesity and induce structural recovery of GM/WM density and WM integrity. It is unknown whether the surgery can promote structural changes in cortical morphometry along with weight-loss. Structural Magnetic Resonance Imaging and surface-based morphometry analysis were used to investigate BS-induced alterations of cortical morphometry in 22 obese participants who were tested before and one month post-BS, and in 21 obese controls (Ctr) without surgery who were tested twice (Baseline and One-month). Results showed that fasting plasma ghrelin, insulin, and leptin levels were significantly reduced post-BS (P < 0.001). Post-BS there were significant decreases in cortical thickness in the precuneus (PFDR < 0.05) that were associated with decreases in BMI. There were also significant increases post-BS in cortical thickness in middle (MFG) and superior (SFG) frontal gyri, superior temporal gyrus (STG), insula and ventral anterior cingulate cortex (vACC); and in cortical volume in left postcentral gyrus (PostCen) and vACC (PFDR < 0.05). Post-BS changes in SFG were associated with decreases in BMI. These findings suggest that structural changes in brain regions implicated in executive control and self-referential processing are associated with BS-induced weight-loss.
AB - Obesity-related brain gray (GM) and white matter (WM) abnormalities have been reported in regions associated with food-intake control and cognitive-emotional regulation. Bariatric surgery (BS) is the most effective way to treat obesity and induce structural recovery of GM/WM density and WM integrity. It is unknown whether the surgery can promote structural changes in cortical morphometry along with weight-loss. Structural Magnetic Resonance Imaging and surface-based morphometry analysis were used to investigate BS-induced alterations of cortical morphometry in 22 obese participants who were tested before and one month post-BS, and in 21 obese controls (Ctr) without surgery who were tested twice (Baseline and One-month). Results showed that fasting plasma ghrelin, insulin, and leptin levels were significantly reduced post-BS (P < 0.001). Post-BS there were significant decreases in cortical thickness in the precuneus (PFDR < 0.05) that were associated with decreases in BMI. There were also significant increases post-BS in cortical thickness in middle (MFG) and superior (SFG) frontal gyri, superior temporal gyrus (STG), insula and ventral anterior cingulate cortex (vACC); and in cortical volume in left postcentral gyrus (PostCen) and vACC (PFDR < 0.05). Post-BS changes in SFG were associated with decreases in BMI. These findings suggest that structural changes in brain regions implicated in executive control and self-referential processing are associated with BS-induced weight-loss.
KW - Bariatric surgery
KW - Cortical morphometry
KW - Linear mixed effects
KW - Obesity
UR - https://www.scopus.com/pages/publications/85048538075
U2 - 10.1007/s11682-018-9904-2
DO - 10.1007/s11682-018-9904-2
M3 - 文章
C2 - 29948904
AN - SCOPUS:85048538075
SN - 1931-7557
VL - 13
SP - 830
EP - 840
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 3
ER -
可持续发展目标 3 良好健康与福祉