TY - GEN
T1 - Spatial weighed element based FEM incorporating a priori information on bioluminescence tomography
AU - Shi, Jin
AU - Tian, Jie
AU - Xu, Min
AU - Yang, Wei
PY - 2008
Y1 - 2008
N2 - Bioluminescence tomography (BLT) is a promising imaging technique which may dynamically and real-timely detect the molecular and cellular activity at the whole-body level in small animal studies. In view of the ill-posedness of the BLT, it is hard to fully reconstruct source density. In addition, the uniqueness theorem on BLT indicates that it is important to employ a priori information for accurate source reconstruction. Hence, we adopt diffuse optical tomography (DOT) technique to provide optical parameters of main tissues as a priori information. Besides, we restrict the range of real source to a permissible region to raise the numerical stability and reduce the ill-posedness of BLT. Next, we forward Spatial Weighed Element based Finite Element Method and compare it's solutions with analytic formula and MOSE. Numerical simulation of homogeneous and heterogeneous phantom demonstrates the source location and density with prior information is better than that not using a priori information.
AB - Bioluminescence tomography (BLT) is a promising imaging technique which may dynamically and real-timely detect the molecular and cellular activity at the whole-body level in small animal studies. In view of the ill-posedness of the BLT, it is hard to fully reconstruct source density. In addition, the uniqueness theorem on BLT indicates that it is important to employ a priori information for accurate source reconstruction. Hence, we adopt diffuse optical tomography (DOT) technique to provide optical parameters of main tissues as a priori information. Besides, we restrict the range of real source to a permissible region to raise the numerical stability and reduce the ill-posedness of BLT. Next, we forward Spatial Weighed Element based Finite Element Method and compare it's solutions with analytic formula and MOSE. Numerical simulation of homogeneous and heterogeneous phantom demonstrates the source location and density with prior information is better than that not using a priori information.
KW - A priori information
KW - Bioluminescence tomography (BLT)
KW - Diffuse optical tomography (DOT)
KW - Spatial weighed element based FEM
UR - https://www.scopus.com/pages/publications/84859812463
U2 - 10.1007/978-3-540-85988-8_104
DO - 10.1007/978-3-540-85988-8_104
M3 - 会议稿件
C2 - 18979828
AN - SCOPUS:84859812463
SN - 354085987X
SN - 9783540859871
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 874
EP - 882
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
T2 - 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Y2 - 6 September 2008 through 10 September 2008
ER -