Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome

Telang Wu; Katrin Töpfer; Shih Wen Lin; Hua Li; Ang Bian; Xiang Y. Zhou; Katherine A. High; Hildegund C.J. Ertl

doi:10.1038/mt.2011.280

Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome

Telang Wu
, Katrin Töpfer
, Shih Wen Lin
, Hua Li
, Ang Bian
, Xiang Y. Zhou
, Katherine A. High
, Hildegund C.J. Ertl^*

^*此作品的通讯作者

Wistar Institute
University of Pennsylvania
German Primate Center – Leibniz Institute for Primate Research
National Institutes of Health
Children's Hospital of Philadelphia
Howard Hughes Medical Institute

科研成果: 期刊稿件 › 文章 › 同行评审

62 引用（Scopus）

摘要

Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8 T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients.

源语言	英语
页（从-至）	572-579
页数	8
期刊	Molecular Therapy
卷	20
期	3
DOI	https://doi.org/10.1038/mt.2011.280
出版状态	已出版 - 3月 2012
已对外发布	是

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abstract = "Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8 T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients.",

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AU - Wu, Telang

AU - Töpfer, Katrin

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AU - Li, Hua

AU - Bian, Ang

AU - Zhou, Xiang Y.

AU - High, Katherine A.

AU - Ertl, Hildegund C.J.

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AB - Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8 T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients.

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Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome

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