TY - JOUR
T1 - Porous Ti-10Mo alloy fabricated by powder metallurgy for promoting bone regeneration
AU - Xu, Wei
AU - Liu, Zhuo
AU - Lu, Xin
AU - Tian, Jingjing
AU - Chen, Gang
AU - Liu, Bowen
AU - Li, Zhou
AU - Qu, Xuanhui
AU - Wen, Cuie
N1 - Publisher Copyright:
© 2019, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Porous Ti-10Mo alloys were fabricated by powder metallurgy using a space-holder method. The pore characteristics, microstructure, mechanical properties, in vitro biocompatibility, and in vivo osseointegration of the fabricated alloys were systematically investigated. The results show that with different weight ratios of the space-holder (NH 4 HCO 3 ) added, all of the porous Ti-10Mo alloys sintered at 1,300°C exhibited a typical Widmanstätten microstructure. The porosity and average pore size of the porous structures can be controlled in the range of 50.8%–66.9% and 70.1–381.4 μm, respectively. The Ti-10Mo alloy with 63.4% porosity exhibited the most suitable mechanical properties for implant applications with an elastic modulus of 2.9 GPa and a compressive yield strength of 127.5 MPa. In vitro, the alloyconditioned medium showed no deleterious effect on the cell proliferation. The cell viability in this medium was higher than that of the reference group, suggesting non-toxicity and good biological characteristics of the alloy specimens. In vivo, after eight weeks’ implantation, new bone tissue formed surrounding the alloy implants, and no noticeable inflammation was observed at the implantation site. The bone bonding strength of the porous Ti-10Mo alloy increased over time from 46.6 N at two weeks to 176.4 N at eight weeks. Suitable mechanical properties together with excellent biocompatibility in vitro and osteointegration in vivo make the porous Ti-10Mo fabricated by powder metallurgy an attractive orthopedic implant alloy.
AB - Porous Ti-10Mo alloys were fabricated by powder metallurgy using a space-holder method. The pore characteristics, microstructure, mechanical properties, in vitro biocompatibility, and in vivo osseointegration of the fabricated alloys were systematically investigated. The results show that with different weight ratios of the space-holder (NH 4 HCO 3 ) added, all of the porous Ti-10Mo alloys sintered at 1,300°C exhibited a typical Widmanstätten microstructure. The porosity and average pore size of the porous structures can be controlled in the range of 50.8%–66.9% and 70.1–381.4 μm, respectively. The Ti-10Mo alloy with 63.4% porosity exhibited the most suitable mechanical properties for implant applications with an elastic modulus of 2.9 GPa and a compressive yield strength of 127.5 MPa. In vitro, the alloyconditioned medium showed no deleterious effect on the cell proliferation. The cell viability in this medium was higher than that of the reference group, suggesting non-toxicity and good biological characteristics of the alloy specimens. In vivo, after eight weeks’ implantation, new bone tissue formed surrounding the alloy implants, and no noticeable inflammation was observed at the implantation site. The bone bonding strength of the porous Ti-10Mo alloy increased over time from 46.6 N at two weeks to 176.4 N at eight weeks. Suitable mechanical properties together with excellent biocompatibility in vitro and osteointegration in vivo make the porous Ti-10Mo fabricated by powder metallurgy an attractive orthopedic implant alloy.
KW - Porosity
KW - cell cytotoxicity
KW - osteointegration
KW - powder metallurgy
KW - structure characterization
UR - https://www.scopus.com/pages/publications/85060980867
U2 - 10.1007/s40843-018-9394-9
DO - 10.1007/s40843-018-9394-9
M3 - 文章
AN - SCOPUS:85060980867
SN - 2095-8226
VL - 62
SP - 1053
EP - 1064
JO - Science China Materials
JF - Science China Materials
IS - 7
ER -