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Nanoporous aluminum anodic oxide-based optical biosensor for real-time detection of Troponin T

  • Se Hyuk Yeom*
  • , Byoung Ho Kang
  • , Kyu Jin Kim
  • , Heng Yuan
  • , Ok Geun Kim
  • , Ma Eum Han
  • , Dae Hyuk Kwon
  • , Shin Won Kang
  • *此作品的通讯作者
  • Kyungpook National University
  • Kyungil University

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

A highly sensitive and real-time monitoring biosensor detecting Troponin T was developed using a nanoporous aluminum anodic oxide (AAO) layer as a sensing membrane. Troponin T is known as an unusual myocardial injury marker, and as a protein that forms the complexes with Troponin I, and Troponin C, which control muscle contraction. The device using interferometry and localized surface plasmon resonance (LSPR) phenomenon has high sensitivity and selectivity compared with a single sensing principal device. To fabricate a sensing membrane, two-step anodizing method was conducted. Au deposition was conducted to induce the LSPR phenomenon and to immobilize Troponin T antibody by SAM method. A real time sensing system was consisted of optical spectrometer and an optical fiber reflectance probe. We confirmed that the developed biosensor system had high sensitivity to detect Troponin T.

源语言英语
主期刊名IEEE Sensors 2011 Conference, SENSORS 2011
288-291
页数4
DOI
出版状态已出版 - 2011
已对外发布
活动10th IEEE SENSORS Conference 2011, SENSORS 2011 - Limerick, 爱尔兰
期限: 28 10月 201131 10月 2011

出版系列

姓名Proceedings of IEEE Sensors

会议

会议10th IEEE SENSORS Conference 2011, SENSORS 2011
国家/地区爱尔兰
Limerick
时期28/10/1131/10/11

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