Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry

Linfeng Xu; Xiangpeng Li; Wenzong Li; Kai chun Chang; Hyunjun Yang; Nannan Tao; Pengfei Zhang; Emory M. Payne; Cyrus Modavi; Jacqueline Humphries; Chia Wei Lu; Adam R. Abate

doi:10.1002/adma.202108194

Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry

Linfeng Xu
, Xiangpeng Li
, Wenzong Li
, Kai chun Chang
, Hyunjun Yang
, Nannan Tao
, Pengfei Zhang
, Emory M. Payne
, Cyrus Modavi
, Jacqueline Humphries
, Chia Wei Lu
, Adam R. Abate^*

^*此作品的通讯作者

University of California at San Francisco
Amyris Inc.
Bruker Corporation
University of Michigan, Ann Arbor
Chan Zuckerberg Biohub

科研成果: 期刊稿件 › 文章 › 同行评审

13 引用（Scopus）

摘要

Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.

源语言	英语
文章编号	2108194
期刊	Advanced Materials
卷	34
期	12
DOI	https://doi.org/10.1002/adma.202108194
出版状态	已出版 - 24 3月 2022
已对外发布	是

访问文件

10.1002/adma.202108194

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{7fb11baea5df487b913a3ddd6ecf9e74,

title = "Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry",

abstract = "Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.",

keywords = "mass spectrometry imaging, microbowls, microwell arrays",

author = "Linfeng Xu and Xiangpeng Li and Wenzong Li and Chang, \{Kai chun\} and Hyunjun Yang and Nannan Tao and Pengfei Zhang and Payne, \{Emory M.\} and Cyrus Modavi and Jacqueline Humphries and Lu, \{Chia Wei\} and Abate, \{Adam R.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.",

year = "2022",

month = mar,

day = "24",

doi = "10.1002/adma.202108194",

language = "英语",

volume = "34",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry

AU - Xu, Linfeng

AU - Li, Xiangpeng

AU - Li, Wenzong

AU - Chang, Kai chun

AU - Yang, Hyunjun

AU - Tao, Nannan

AU - Zhang, Pengfei

AU - Payne, Emory M.

AU - Modavi, Cyrus

AU - Humphries, Jacqueline

AU - Lu, Chia Wei

AU - Abate, Adam R.

PY - 2022/3/24

Y1 - 2022/3/24

N2 - Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.

AB - Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.

KW - mass spectrometry imaging

KW - microbowls

KW - microwell arrays

UR - https://www.scopus.com/pages/publications/85124552628

U2 - 10.1002/adma.202108194

DO - 10.1002/adma.202108194

M3 - 文章

C2 - 35045587

AN - SCOPUS:85124552628

SN - 0935-9648

VL - 34

JO - Advanced Materials

JF - Advanced Materials

IS - 12

M1 - 2108194

ER -

Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry

摘要

访问文件

其它文件与链接

指纹

引用此