TY - JOUR
T1 - Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum
AU - Qiao, Lin
AU - Gao, Lirong
AU - Zheng, Minghui
AU - Xia, Dan
AU - Li, Jingguang
AU - Zhang, Lei
AU - Wu, Yongning
AU - Wang, Runhua
AU - Cui, Lili
AU - Xu, Chi
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/9/4
Y1 - 2018/9/4
N2 - Multiple studies have demonstrated the occurrences of short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in environmental matrixes, but human internal exposure to them has been studied rarely. Mass fractions and congener group patterns of SCCPs and MCCPs in paired maternal and cord serum were studied for the first time to investigate the placental transport mechanism and prenatal exposure risks of CPs. Samples were collected in Beijing, China, and analyzed using two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. SCCP and MCCP mass fractions in maternal serum were 21.7-373 and 3.76-31.8 ng/g ww, respectively. They were 8.51-107 and 1.33-12.9 ng/g ww, respectively, in cord serum. Significant positive correlation between SCCP and MCCP levels in maternal serum was found (p < 0.01), suggesting SCCPs and MCCPs may undergo similar accumulation, transfer, and transformation pathways. The predominant congener groups for SCCP and MCCP in maternal serum were C10-11Cl6-7 and C14Cl7-8. The homologue profiles of CPs in cord serum were similar but with varied contribution percentage compared with those in maternal serum. By calculating and comparing cord-maternal serum ratios for each individual congener group, passive diffusion was recognized to be the possible placental transport form. The relationships between CP and thyroid hormone concentrations (THs) indicated that exposure to CPs might affect circulating TSHs. C9-CPs were also detected, improving our understanding of CPs in human serum.
AB - Multiple studies have demonstrated the occurrences of short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in environmental matrixes, but human internal exposure to them has been studied rarely. Mass fractions and congener group patterns of SCCPs and MCCPs in paired maternal and cord serum were studied for the first time to investigate the placental transport mechanism and prenatal exposure risks of CPs. Samples were collected in Beijing, China, and analyzed using two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. SCCP and MCCP mass fractions in maternal serum were 21.7-373 and 3.76-31.8 ng/g ww, respectively. They were 8.51-107 and 1.33-12.9 ng/g ww, respectively, in cord serum. Significant positive correlation between SCCP and MCCP levels in maternal serum was found (p < 0.01), suggesting SCCPs and MCCPs may undergo similar accumulation, transfer, and transformation pathways. The predominant congener groups for SCCP and MCCP in maternal serum were C10-11Cl6-7 and C14Cl7-8. The homologue profiles of CPs in cord serum were similar but with varied contribution percentage compared with those in maternal serum. By calculating and comparing cord-maternal serum ratios for each individual congener group, passive diffusion was recognized to be the possible placental transport form. The relationships between CP and thyroid hormone concentrations (THs) indicated that exposure to CPs might affect circulating TSHs. C9-CPs were also detected, improving our understanding of CPs in human serum.
UR - https://www.scopus.com/pages/publications/85052292874
U2 - 10.1021/acs.est.8b02839
DO - 10.1021/acs.est.8b02839
M3 - 文章
C2 - 30073828
AN - SCOPUS:85052292874
SN - 0013-936X
VL - 52
SP - 10097
EP - 10103
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 17
ER -