Magnetically Controlled Nanorobotic Swarm for the Glioma Therapy∗

Gliomas have a specific pathogenesis, high mortality rate and very low cure rate. In the current treatment of glioma, the presence of the blood-brain barrier severely hinders drug delivery. To address this problem, we propose a drug delivery strategy via temozolomide-loaded micro-nano robots, which is expected to break the blood-brain barrier and precisely enrich in the glioma region. We have validated in vitro the effect of driving control of the drug-loaded magnetically controlled micro-nano robot. A specially designed magnetic drive control system using a rotating magnetic field allows for cluster control of the drug-loaded magnetically controlled micro-nano robots, finding a relationship between the speed of movement and the frequency of magnetic field rotation, and a preliminary attempt to break the blood-brain barrier in healthy mice. This study provides a good solution strategy for drug-laden magnetically controlled micro-nano robots to break the blood-brain barrier for the treatment of glioma.