Lepton flavor of four-fermion operator and fermion portal dark matter**Gang Li and Xiang Zhao are supported by the National Natural Science Foundation of China (12347105, 12505127), the Guangdong Basic and Applied Basic Research Foundation (2024A1515012668). The work of Jia Liu is supported by the National Science Foundation of China (12235001, 12475103) and State Key Laboratory of Nuclear Physics and Technology (NPT2025ZX11). The work of Xiao-Ping Wang is supported by National Science Foundation of China (12375095) and the Fundamental Research Funds for the Central Universities

This study investigates the ultraviolet realization of semileptonic four-fermion operator (Formula presented) that incorporates Majorana dark matter (DM) in both lepton-flavor-conserving (LFC) and lepton-flavor-violating (LFV) scenarios at the one-loop level via box diagram, thereby effectively alleviating the lower bounds on the new physics scale. In addition, we investigate the interplay between model-independent constraints on the Wilson coefficients and DM direct detection, relic density, and collider searches in the context of fermion portal DM model with two mediators. We found that both the projected future constraint on the LFC Wilson coefficient (Formula presented) (Formula presented) from the measurements of neutrino non-standard interaction in the next-generation neutrino oscillation experiments, and the LFV constraint (Formula presented) from ongoing charged-lepton-flavor-violation searches, provide a complementary exploration of the parameter space encompassing the DM and scalar masses. With a colored mediator mass of approximately (Formula presented), the sensitivity of the indirect constraints on the four-fermion operator can surpass those of collider searches and DM direct detection, in scenarios where the masses of the DM and scalar are close. By ensuring the correct DM relic density, however, we find that the collider searches and DM direct detection are more sensitive to the electroweak-scale DM and scalar than indirect constraints.