TY - JOUR
T1 - Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential
T2 - A Study Using In-Vitro and Numerical Methods
AU - Li, Shulei
AU - Jin, Donghai
AU - Gui, Xingmin
AU - Liu, Guangmao
AU - Hao, Jianqiang
AU - Jiang, Xihang
N1 - Publisher Copyright:
© 1964-2012 IEEE.
PY - 2025
Y1 - 2025
N2 - Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HIave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HIave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.
AB - Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HIave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HIave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.
KW - Heart rate
KW - hemolytic potential
KW - in-vitro experiments
KW - numerical simulations
KW - pump dynamic characteristics
UR - https://www.scopus.com/pages/publications/85216320593
U2 - 10.1109/TBME.2024.3467924
DO - 10.1109/TBME.2024.3467924
M3 - 文章
C2 - 40031179
AN - SCOPUS:85216320593
SN - 0018-9294
VL - 72
SP - 689
EP - 704
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 2
ER -