Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

Dylan J. Richards; Yang Li; Charles M. Kerr; Jenny Yao; Gyda C. Beeson; Robert C. Coyle; Xun Chen; Jia Jia; Brooke Damon; Robert Wilson; E. Starr Hazard; Gary Hardiman; Donald R. Menick; Craig C. Beeson; Hai Yao; Tong Ye; Ying Mei

doi:10.1038/s41551-020-0539-4

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

Dylan J. Richards
, Yang Li
, Charles M. Kerr
, Jenny Yao
, Gyda C. Beeson
, Robert C. Coyle
, Xun Chen
, Jia Jia
, Brooke Damon
, Robert Wilson
, E. Starr Hazard
, Gary Hardiman
, Donald R. Menick
, Craig C. Beeson
, Hai Yao
, Tong Ye^*
, Ying Mei

^*此作品的通讯作者

Clemson University
Johnson & Johnson
Medical University of South Carolina
Harvard University
Queen's University Belfast

科研成果: 期刊稿件 › 文章 › 同行评审

390 引用（Scopus）

摘要

Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.

源语言	英语
页（从-至）	446-462
页数	17
期刊	Nature Biomedical Engineering
卷	4
期	4
DOI	https://doi.org/10.1038/s41551-020-0539-4
出版状态	已出版 - 1 4月 2020
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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Richards, D. J., Li, Y., Kerr, C. M., Yao, J., Beeson, G. C., Coyle, R. C., Chen, X., Jia, J., Damon, B., Wilson, R., Starr Hazard, E., Hardiman, G., Menick, D. R., Beeson, C. C., Yao, H., Ye, T., & Mei, Y. (2020). Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity. Nature Biomedical Engineering, 4(4), 446-462. https://doi.org/10.1038/s41551-020-0539-4

@article{5df2898f7b1f479ea4d8b2632c09e8ee,

title = "Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity",

abstract = "Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.",

author = "Richards, \{Dylan J.\} and Yang Li and Kerr, \{Charles M.\} and Jenny Yao and Beeson, \{Gyda C.\} and Coyle, \{Robert C.\} and Xun Chen and Jia Jia and Brooke Damon and Robert Wilson and \{Starr Hazard\}, E. and Gary Hardiman and Menick, \{Donald R.\} and Beeson, \{Craig C.\} and Hai Yao and Tong Ye and Ying Mei",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2020",

month = apr,

day = "1",

doi = "10.1038/s41551-020-0539-4",

language = "英语",

volume = "4",

pages = "446--462",

journal = "Nature Biomedical Engineering",

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Richards, DJ, Li, Y, Kerr, CM, Yao, J, Beeson, GC, Coyle, RC, Chen, X, Jia, J, Damon, B, Wilson, R, Starr Hazard, E, Hardiman, G, Menick, DR, Beeson, CC, Yao, H, Ye, T & Mei, Y 2020, 'Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity', Nature Biomedical Engineering, 卷 4, 号码 4, 页码 446-462. https://doi.org/10.1038/s41551-020-0539-4

TY - JOUR

T1 - Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

AU - Richards, Dylan J.

AU - Li, Yang

AU - Kerr, Charles M.

AU - Yao, Jenny

AU - Beeson, Gyda C.

AU - Coyle, Robert C.

AU - Chen, Xun

AU - Jia, Jia

AU - Damon, Brooke

AU - Wilson, Robert

AU - Starr Hazard, E.

AU - Hardiman, Gary

AU - Menick, Donald R.

AU - Beeson, Craig C.

AU - Yao, Hai

AU - Ye, Tong

AU - Mei, Ying

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.

AB - Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated with the neurotransmitter noradrenaline model the structure of the human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and recapitulate hallmarks of myocardial infarction (in particular, pathological metabolic shifts, fibrosis and calcium handling) at the transcriptomic, structural and functional levels. We also show that the organoids can model hypoxia-enhanced doxorubicin cardiotoxicity. Human organoids that model diseases with non-genetic pathological factors could help with drug screening and development.

UR - https://www.scopus.com/pages/publications/85083481579

U2 - 10.1038/s41551-020-0539-4

DO - 10.1038/s41551-020-0539-4

M3 - 文章

C2 - 32284552

AN - SCOPUS:85083481579

SN - 2157-846X

VL - 4

SP - 446

EP - 462

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 4

ER -

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

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