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Fluorescence molecular tomography based on L2,1-norm method for morphological reconstruction

  • Beijing Jiaotong University
  • CAS - Institute of Automation

科研成果: 书/报告/会议事项章节会议稿件同行评审

摘要

With the development of fluorescence molecular tomography (FMT), it has become an important tool for life science research. Many methods were developed to improve the reconstruction performance of FMT. However, these methods only focus on the accuracy and speed of the reconstruction, while ignoring the morphological information of the tumor. In this paper, the modified L2,1-norm method were adopted to reconstruct the morphology of the mouse orthotopic glioma. To verify the L2,1-norm method, we carried out the simulation experiment and the in vivo orthotopic glioma mouse experiment. The iterated shrinkage (IS) method and the Tikhonov-based method were implemented for comparison. The results show that the modified L2,1-norm method can obtain more accurate reconstruction in both tumor location and morphology reconstruction. We believe that the morphological reconstruction of FMT will provide more potential for preclinical research.

源语言英语
主期刊名Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII
编辑James F. Leary, Daniel L. Farkas, Attila Tarnok
出版商SPIE
ISBN(电子版)9781510624047
DOI
出版状态已出版 - 2019
活动Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII 2019 - San Francisco, 美国
期限: 4 2月 20196 2月 2019

出版系列

姓名Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10881
ISSN(印刷版)1605-7422

会议

会议Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII 2019
国家/地区美国
San Francisco
时期4/02/196/02/19

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