TY - JOUR
T1 - Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy
AU - Yu, Xinyang
AU - Qi, Shaolong
AU - Cao, Fangfang
AU - Yang, Kai
AU - Li, Hongjian
AU - Peng, Kun
AU - Liu, Zhida
AU - Bai, Bing
AU - Buljan, Marija
AU - Chen, Xiaoyuan
AU - Yu, Guocan
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/11/27
Y1 - 2023/11/27
N2 - Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8+ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.
AB - Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8+ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.
KW - cancer immunotherapy
KW - endoplasmic reticulum stress
KW - host−guest chemistry
KW - immunogenic cell death
KW - supramolecular nanomedicine
UR - https://www.scopus.com/pages/publications/85178153651
U2 - 10.1021/jacsau.3c00515
DO - 10.1021/jacsau.3c00515
M3 - 文章
AN - SCOPUS:85178153651
SN - 2691-3704
VL - 3
SP - 3181
EP - 3193
JO - JACS Au
JF - JACS Au
IS - 11
ER -
可持续发展目标 3 良好健康与福祉