Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release

Fangfang Cao; Enguo Ju; Chaoqun Liu; Wei Li; Yan Zhang; Kai Dong; Zhen Liu; Jinsong Ren; Xiaogang Qu

doi:10.1039/c7nr00073a

Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release

Fangfang Cao
, Enguo Ju
, Chaoqun Liu
, Wei Li
, Yan Zhang
, Kai Dong
, Zhen Liu
, Jinsong Ren^*
, Xiaogang Qu

^*此作品的通讯作者

CAS - Changchun Institute of Applied Chemistry
University of Science and Technology of China
University of Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

114 引用（Scopus）

摘要

Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.

源语言	英语
页（从-至）	4128-4134
页数	7
期刊	Nanoscale
卷	9
期	12
DOI	https://doi.org/10.1039/c7nr00073a
出版状态	已出版 - 28 3月 2017
已对外发布	是

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title = "Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release",

abstract = "Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74\%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.",

author = "Fangfang Cao and Enguo Ju and Chaoqun Liu and Wei Li and Yan Zhang and Kai Dong and Zhen Liu and Jinsong Ren and Xiaogang Qu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

month = mar,

day = "28",

doi = "10.1039/c7nr00073a",

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T1 - Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release

AU - Cao, Fangfang

AU - Ju, Enguo

AU - Liu, Chaoqun

AU - Li, Wei

AU - Zhang, Yan

AU - Dong, Kai

AU - Liu, Zhen

AU - Ren, Jinsong

AU - Qu, Xiaogang

PY - 2017/3/28

Y1 - 2017/3/28

N2 - Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.

AB - Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.

UR - https://www.scopus.com/pages/publications/85016120513

U2 - 10.1039/c7nr00073a

DO - 10.1039/c7nr00073a

M3 - 文章

C2 - 28281716

AN - SCOPUS:85016120513

SN - 2040-3364

VL - 9

SP - 4128

EP - 4134

JO - Nanoscale

JF - Nanoscale

IS - 12

ER -

Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release

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