Discovery of susceptibility loci associated with tuberculosis in Han Chinese

Hui Qi; Yong Biao Zhang; Lin Sun; Cheng Chen; Biao Xu; Fang Xu; Jia Wen Liu; Jin Cheng Liu; Chen Chen; Wei Wei Jiao; Chen Shen; Jing Xiao; Jie Qiong Li; Ya Jie Guo; Yong Hong Wang; Qin Jing Li; Qing Qin Yin; Ying Jia Li; Ting Wang; Xing Yun Wang; Ming Liang Gu; Jun Yu; A. Dong Shen

doi:10.1093/hmg/ddx365

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

Hui Qi
, Yong Biao Zhang
, Lin Sun
, Cheng Chen
, Biao Xu
, Fang Xu
, Jia Wen Liu
, Jin Cheng Liu
, Chen Chen
, Wei Wei Jiao
, Chen Shen
, Jing Xiao
, Jie Qiong Li
, Ya Jie Guo
, Yong Hong Wang
, Qin Jing Li
, Qing Qin Yin
, Ying Jia Li
, Ting Wang
, Xing Yun Wang

Ming Liang Gu, Jun Yu, A. Dong Shen^*

^*此作品的通讯作者

Capital Medical University
CAS - Beijing Institute of Genomics
Shenzhen Center for Disease Control and Prevention
Fudan University
Karolinska Institutet
Beijing Geriatric Hospital
Tuberculosis Hospital of Shaanxi Province 710100

科研成果: 期刊稿件 › 文章 › 同行评审

44 引用（Scopus）

摘要

Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10^-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

源语言	英语
页（从-至）	4752-4763
页数	12
期刊	Human Molecular Genetics
卷	26
期	23
DOI	https://doi.org/10.1093/hmg/ddx365
出版状态	已出版 - 1 12月 2017
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1093/hmg/ddx365

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Qi, H., Zhang, Y. B., Sun, L., Chen, C., Xu, B., Xu, F., Liu, J. W., Liu, J. C., Chen, C., Jiao, W. W., Shen, C., Xiao, J., Li, J. Q., Guo, Y. J., Wang, Y. H., Li, Q. J., Yin, Q. Q., Li, Y. J., Wang, T., ... Shen, A. D. (2017). Discovery of susceptibility loci associated with tuberculosis in Han Chinese. Human Molecular Genetics, 26(23), 4752-4763. https://doi.org/10.1093/hmg/ddx365

@article{59d17647275e439cadf54f4c49176ead,

title = "Discovery of susceptibility loci associated with tuberculosis in Han Chinese",

abstract = "Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.",

author = "Hui Qi and Zhang, \{Yong Biao\} and Lin Sun and Cheng Chen and Biao Xu and Fang Xu and Liu, \{Jia Wen\} and Liu, \{Jin Cheng\} and Chen Chen and Jiao, \{Wei Wei\} and Chen Shen and Jing Xiao and Li, \{Jie Qiong\} and Guo, \{Ya Jie\} and Wang, \{Yong Hong\} and Li, \{Qin Jing\} and Yin, \{Qing Qin\} and Li, \{Ying Jia\} and Ting Wang and Wang, \{Xing Yun\} and Gu, \{Ming Liang\} and Jun Yu and Shen, \{A. Dong\}",

year = "2017",

month = dec,

day = "1",

doi = "10.1093/hmg/ddx365",

language = "英语",

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Qi, H, Zhang, YB, Sun, L, Chen, C, Xu, B, Xu, F, Liu, JW, Liu, JC, Chen, C, Jiao, WW, Shen, C, Xiao, J, Li, JQ, Guo, YJ, Wang, YH, Li, QJ, Yin, QQ, Li, YJ, Wang, T, Wang, XY, Gu, ML, Yu, J & Shen, AD 2017, 'Discovery of susceptibility loci associated with tuberculosis in Han Chinese', Human Molecular Genetics, 卷 26, 号码 23, 页码 4752-4763. https://doi.org/10.1093/hmg/ddx365

TY - JOUR

T1 - Discovery of susceptibility loci associated with tuberculosis in Han Chinese

AU - Qi, Hui

AU - Zhang, Yong Biao

AU - Sun, Lin

AU - Chen, Cheng

AU - Xu, Biao

AU - Xu, Fang

AU - Liu, Jia Wen

AU - Liu, Jin Cheng

AU - Chen, Chen

AU - Jiao, Wei Wei

AU - Shen, Chen

AU - Xiao, Jing

AU - Li, Jie Qiong

AU - Guo, Ya Jie

AU - Wang, Yong Hong

AU - Li, Qin Jing

AU - Yin, Qing Qin

AU - Li, Ying Jia

AU - Wang, Ting

AU - Wang, Xing Yun

AU - Gu, Ming Liang

AU - Yu, Jun

AU - Shen, A. Dong

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

AB - Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

UR - https://www.scopus.com/pages/publications/85042232154

U2 - 10.1093/hmg/ddx365

DO - 10.1093/hmg/ddx365

M3 - 文章

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AN - SCOPUS:85042232154

SN - 0964-6906

VL - 26

SP - 4752

EP - 4763

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 23

ER -

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

摘要

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