Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers

Longgang Wang; Juan Zhang; Weifeng Lin; Zhen Wang; Shengfu Chen

doi:10.1002/admi.201300059

Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers

Longgang Wang
, Juan Zhang
, Weifeng Lin
, Zhen Wang
, Shengfu Chen^*

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

A full layer of zwitterionic carboxybetaine-modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein-like molecules to obtain therapeutic function.

源语言	英语
文章编号	1300059
期刊	Advanced Materials Interfaces
卷	1
期	1
DOI	https://doi.org/10.1002/admi.201300059
出版状态	已出版 - 1 2月 2014
已对外发布	是

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abstract = "A full layer of zwitterionic carboxybetaine-modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein-like molecules to obtain therapeutic function.",

keywords = "dendrimers, protein mimic, RGD, specific targeting, zwitterionic",

author = "Longgang Wang and Juan Zhang and Weifeng Lin and Zhen Wang and Shengfu Chen",

note = "Publisher Copyright: {\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

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T1 - Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers

AU - Wang, Longgang

AU - Zhang, Juan

AU - Lin, Weifeng

AU - Wang, Zhen

AU - Chen, Shengfu

PY - 2014/2/1

Y1 - 2014/2/1

N2 - A full layer of zwitterionic carboxybetaine-modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein-like molecules to obtain therapeutic function.

AB - A full layer of zwitterionic carboxybetaine-modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein-like molecules to obtain therapeutic function.

KW - dendrimers

KW - protein mimic

KW - RGD

KW - specific targeting

KW - zwitterionic

UR - https://www.scopus.com/pages/publications/84930787884

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DO - 10.1002/admi.201300059

M3 - 文章

AN - SCOPUS:84930787884

SN - 2196-7350

VL - 1

JO - Advanced Materials Interfaces

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Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers

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