Detection of HCG-antigen based on enhanced photoluminescence of hierarchical ZnO arrays

Xiang Yan; Zhongbing Huang; Mian He; Xiaoming Liao; Chaoqun Zhang; Guangfu Yin; Jianwen Gu

doi:10.1016/j.colsurfb.2011.08.027

Detection of HCG-antigen based on enhanced photoluminescence of hierarchical ZnO arrays

Xiang Yan
, Zhongbing Huang^*
, Mian He
, Xiaoming Liao
, Chaoqun Zhang
, Guangfu Yin
, Jianwen Gu

^*此作品的通讯作者

College of Materials Science and Engineering
The Military General Hospital of Chengdu PLA

科研成果: 期刊稿件 › 文章 › 同行评审

21 引用（Scopus）

摘要

Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160. ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns. After the specific combination between antigen and antibody on hierarchical ZnO arrays, the enhanced PL intensity of ZnO arrays was also basically linear with the concentration of HCG antigen. Thus, detection of HCG antigen in the range of 2-20. ng/mL was achieved based on PL intensity enhancement, suggesting that the prepared ZnO arrays are envisioned to be applied in the detection of early tumor markers in future.

源语言	英语
页（从-至）	86-92
页数	7
期刊	Colloids and Surfaces B: Biointerfaces
卷	89
期	1
DOI	https://doi.org/10.1016/j.colsurfb.2011.08.027
出版状态	已出版 - 1 1月 2012
已对外发布	是

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title = "Detection of HCG-antigen based on enhanced photoluminescence of hierarchical ZnO arrays",

abstract = "Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160. ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns. After the specific combination between antigen and antibody on hierarchical ZnO arrays, the enhanced PL intensity of ZnO arrays was also basically linear with the concentration of HCG antigen. Thus, detection of HCG antigen in the range of 2-20. ng/mL was achieved based on PL intensity enhancement, suggesting that the prepared ZnO arrays are envisioned to be applied in the detection of early tumor markers in future.",

keywords = "Early detection, HCG antibody-antigen, Hierarchical ZnO column arrays, Photoluminescence",

author = "Xiang Yan and Zhongbing Huang and Mian He and Xiaoming Liao and Chaoqun Zhang and Guangfu Yin and Jianwen Gu",

year = "2012",

month = jan,

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doi = "10.1016/j.colsurfb.2011.08.027",

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TY - JOUR

T1 - Detection of HCG-antigen based on enhanced photoluminescence of hierarchical ZnO arrays

AU - Yan, Xiang

AU - Huang, Zhongbing

AU - He, Mian

AU - Liao, Xiaoming

AU - Zhang, Chaoqun

AU - Yin, Guangfu

AU - Gu, Jianwen

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160. ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns. After the specific combination between antigen and antibody on hierarchical ZnO arrays, the enhanced PL intensity of ZnO arrays was also basically linear with the concentration of HCG antigen. Thus, detection of HCG antigen in the range of 2-20. ng/mL was achieved based on PL intensity enhancement, suggesting that the prepared ZnO arrays are envisioned to be applied in the detection of early tumor markers in future.

AB - Specific antibody of Human chorionic gonadotrophin (HCG) was conjugated onto hierarchical ZnO arrays through the carbodiimide technique, and the photoluminescence (PL) intensity of ZnO arrays were enhanced linearly with the linked antibody concentration in the range of 40-160. ng/mL, which resulted from the nano sheet structure and rough surface in hierarchical ZnO columns. After the specific combination between antigen and antibody on hierarchical ZnO arrays, the enhanced PL intensity of ZnO arrays was also basically linear with the concentration of HCG antigen. Thus, detection of HCG antigen in the range of 2-20. ng/mL was achieved based on PL intensity enhancement, suggesting that the prepared ZnO arrays are envisioned to be applied in the detection of early tumor markers in future.

KW - Early detection

KW - HCG antibody-antigen

KW - Hierarchical ZnO column arrays

KW - Photoluminescence

UR - https://www.scopus.com/pages/publications/80055003085

U2 - 10.1016/j.colsurfb.2011.08.027

DO - 10.1016/j.colsurfb.2011.08.027

M3 - 文章

C2 - 21944543

AN - SCOPUS:80055003085

SN - 0927-7765

VL - 89

SP - 86

EP - 92

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

Detection of HCG-antigen based on enhanced photoluminescence of hierarchical ZnO arrays

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