TY - JOUR
T1 - Design and characterizations of novel biodegradable ternary Zn-based alloys with IIA nutrient alloying elements Mg, Ca and Sr
AU - Li, Huafang
AU - Yang, Hongtao
AU - Zheng, Yufeng
AU - Zhou, Feiyu
AU - Qiu, Kejin
AU - Wang, Xiang
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/15
Y1 - 2015/10/15
N2 - Apart from the industrial and automotive applications, Zn and Zn-based alloys are considered as a new kind of potential biodegradable material quite recently. However, one drawback of pure Zn as potential biodegradable metal lies in that pure Zn has quite low strength and plasticity. In the present study, three important IIA essential nutrient elements Mg, Ca and Sr and hot-rolling and hot-extrusion thermal deformations have been applied to overcome the drawback of pure Zn and benefit the biocompatibility of Zn-based potential implants. The microstructure, mechanical properties, corrosion behavior, hemocompatibility, in vitro cytocompatibility were studied systematically to investigate their feasibility as bioabsorbable implants. The results showed that the mechanical properties of the ternary Zn-1Mg-1Ca, Zn-1Mg-1Sr and Zn-1Ca-1Sr alloys are much higher than that of pure Zn, owing to both the alloying effects and thermal deformation effects. In vitro hemolytic rate test and cell viability test indicated that the addition of the IIA nutrient alloying elements Mg, Ca and Sr into Zn can benefit their hemocompatibility and cytocompatibility, which would further guarantee the biosafety of these new kind of biodegradable Zn-based implants for future clinical applications.
AB - Apart from the industrial and automotive applications, Zn and Zn-based alloys are considered as a new kind of potential biodegradable material quite recently. However, one drawback of pure Zn as potential biodegradable metal lies in that pure Zn has quite low strength and plasticity. In the present study, three important IIA essential nutrient elements Mg, Ca and Sr and hot-rolling and hot-extrusion thermal deformations have been applied to overcome the drawback of pure Zn and benefit the biocompatibility of Zn-based potential implants. The microstructure, mechanical properties, corrosion behavior, hemocompatibility, in vitro cytocompatibility were studied systematically to investigate their feasibility as bioabsorbable implants. The results showed that the mechanical properties of the ternary Zn-1Mg-1Ca, Zn-1Mg-1Sr and Zn-1Ca-1Sr alloys are much higher than that of pure Zn, owing to both the alloying effects and thermal deformation effects. In vitro hemolytic rate test and cell viability test indicated that the addition of the IIA nutrient alloying elements Mg, Ca and Sr into Zn can benefit their hemocompatibility and cytocompatibility, which would further guarantee the biosafety of these new kind of biodegradable Zn-based implants for future clinical applications.
KW - Biodegradable alloys
KW - Corrosion behavior
KW - Cytocompatibility
KW - Hemocompatibility
KW - Mechanical properties
KW - Metals and alloys
UR - https://www.scopus.com/pages/publications/84941281679
U2 - 10.1016/j.matdes.2015.05.089
DO - 10.1016/j.matdes.2015.05.089
M3 - 文章
AN - SCOPUS:84941281679
SN - 0264-1275
VL - 83
SP - 95
EP - 102
JO - Materials and Design
JF - Materials and Design
ER -