TY - JOUR
T1 - Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects
AU - Feng, Huimin
AU - Ha, Feizai
AU - Hu, Guiping
AU - Wu, Yonghua
AU - Yu, Shanfa
AU - Ji, Zhang
AU - Feng, Weiyue
AU - Wang, Tiancheng
AU - Jia, Guang
N1 - Publisher Copyright:
© 2018 Elsevier GmbH
PY - 2018/12
Y1 - 2018/12
N2 - Objective: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. Methods: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. Results: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects. Conclusions: Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.
AB - Objective: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. Methods: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. Results: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects. Conclusions: Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.
KW - Element homeostasis
KW - Hexavalent chromium exposure
KW - Serum lipoprotein metabolism
UR - https://www.scopus.com/pages/publications/85051623466
U2 - 10.1016/j.jtemb.2018.08.003
DO - 10.1016/j.jtemb.2018.08.003
M3 - 文章
C2 - 30262309
AN - SCOPUS:85051623466
SN - 0946-672X
VL - 50
SP - 384
EP - 392
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
ER -