@inproceedings{63046c803d5c45a1852940cd92e1cf2c,
title = "Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry",
abstract = "The mechanism of bitemporal hemianopia is still unclear. Previous research suggested that the nerve fibre packing pattern may contribute to the selective damage of nasal (crossed) nerve fibres. Numerical models were built using finite element modelling to study the biomechanics of optic nerve fibres. The sensitivity of the mechanical behaviours of the nerve fibres to variations of five parameters in the nerve fibre model were investigated using design of experiments (DOE). Results show that the crossing angle is a very significant factor that affects a wide range of responses of the model. The strain difference between the crossed and the uncrossed nerve fibres may account for the phenomenon of bitemporal hemianopia. This work also highlights the need for more accurate material properties of the tissues in the model and an improved understanding of the microstructure of the optic chiasm.",
keywords = "Bitemporal hemianopia, Chiasmal compression, Design of experiment, Finite element modelling, Multi-scale",
author = "Xiaofei Wang and Neely, \{Andrew J.\} and Mcilwaine, \{Gawn G.\} and Lueck, \{Christian J.\}",
year = "2014",
month = jul,
day = "1",
language = "英语",
series = "11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014",
publisher = "International Center for Numerical Methods in Engineering",
pages = "1688--1697",
editor = "Eugenio Onate and Xavier Oliver and Antonio Huerta",
booktitle = "11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014",
note = "Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014 ; Conference date: 20-07-2014 Through 25-07-2014",
}