TY - JOUR
T1 - Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice
AU - Cheng, Haiyan
AU - Yu, Jianchun
AU - Jiang, Zhiguo
AU - Zhang, Xuezhu
AU - Liu, Cunzhi
AU - Peng, Yingmei
AU - Chen, Fuyan
AU - Qu, You
AU - Jia, Yujie
AU - Tian, Qingfei
AU - Xiao, Chuan
AU - Chu, Qin
AU - Nie, Kun
AU - Kan, Bohong
AU - Hu, Xiaolin
AU - Han, Jingxian
PY - 2008/2/20
Y1 - 2008/2/20
N2 - Senescence-accelerated mouse prone 8 (SAMP8) is an autogenic senile strain characterized by early cognitive impairment and age-related deterioration of learning and memory. To investigate the effect of acupuncture on behavioral changes and brain cell events, male 4-month-old SAMP8 and age-matched homologous normal aging SAMR1 mice were divided into four groups: SAMP8 acupuncture group (Pa), SAMP8 non-acupoint control group (Pn), SAMP8 control group (Pc) and SAMR1 normal control group (Rc). By Morris water maze test, the cognitive deficit of SAMP8 was revealed and significantly improved by "Yiqitiaoxue and Fubenpeiyuan" acupuncture. Meanwhile, by 5′-bromo-2′-deoxyuridine (BrdU) specific immunodetection, the decreased cell proliferation in dentate gyrus (DG) of SAMP8 was greatly enhanced by the therapeutic acupuncture, suggesting acupoint-related specificity. Even though no significant differences were found in ventricular/subventricular zones (VZ/SVZ) of the third ventricle (V3) and lateral ventricle (LV) between groups, we obtained interesting results: a stream-like distribution of newly proliferated cells presented along the dorsum of alveus hippocampi (Alv), extending from LV to corpus callosum (CC), and the therapeutic acupuncture showed a marked effect on this region. Our research suggests that acupuncture can induce different cell proliferation in different brain regions of SAMP8, which brings forth the need to explore further for the mechanism of cognitive deficits and acupuncture intervention in this field.
AB - Senescence-accelerated mouse prone 8 (SAMP8) is an autogenic senile strain characterized by early cognitive impairment and age-related deterioration of learning and memory. To investigate the effect of acupuncture on behavioral changes and brain cell events, male 4-month-old SAMP8 and age-matched homologous normal aging SAMR1 mice were divided into four groups: SAMP8 acupuncture group (Pa), SAMP8 non-acupoint control group (Pn), SAMP8 control group (Pc) and SAMR1 normal control group (Rc). By Morris water maze test, the cognitive deficit of SAMP8 was revealed and significantly improved by "Yiqitiaoxue and Fubenpeiyuan" acupuncture. Meanwhile, by 5′-bromo-2′-deoxyuridine (BrdU) specific immunodetection, the decreased cell proliferation in dentate gyrus (DG) of SAMP8 was greatly enhanced by the therapeutic acupuncture, suggesting acupoint-related specificity. Even though no significant differences were found in ventricular/subventricular zones (VZ/SVZ) of the third ventricle (V3) and lateral ventricle (LV) between groups, we obtained interesting results: a stream-like distribution of newly proliferated cells presented along the dorsum of alveus hippocampi (Alv), extending from LV to corpus callosum (CC), and the therapeutic acupuncture showed a marked effect on this region. Our research suggests that acupuncture can induce different cell proliferation in different brain regions of SAMP8, which brings forth the need to explore further for the mechanism of cognitive deficits and acupuncture intervention in this field.
KW - 5′-bromo-2′-deoxyuridine (BrdU)
KW - Acupuncture
KW - Hippocampas dentate gyrus (DG)
KW - Morris water maze
KW - Senescence-accelerated mice prone 8 (SAMP8)
KW - Ventricular/subventricular zone (VZ/SVZ)
UR - https://www.scopus.com/pages/publications/39149107753
U2 - 10.1016/j.neulet.2007.12.009
DO - 10.1016/j.neulet.2007.12.009
M3 - 文章
C2 - 18215464
AN - SCOPUS:39149107753
SN - 0304-3940
VL - 432
SP - 111
EP - 116
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -