@inproceedings{4f91065060a5494ab0854bfbfdaaf8a4,
title = "A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts",
abstract = "Our previous study has shown that Ultraviolet-A (UVA) irradiation induces heme oxygenase 1 (HO-1) expression in cultured human primary skin fibroblasts FEK4. In the present study, we demonstrate a coordinated induction of HO-1 and NF-E2-related factor 2 (Nrf2) following UVA irradiation or hemin treatment. The induction of HO-1 by either UVA irradiation or hemin treatment was largely abolished by down-regulation of Nrf2 with its targeted short interfering RNA (siNrf2). The study further reveals that knockdown of Nrf2 protein increased UVA-induced cell death measured by MTS assay. These findings together indicate that Nrf2-mediated induction of HO-1 expression may provide a cytoprotection for human skin cells from oxidative damage.",
keywords = "FEK4, hemin, HO-1, Nrf2, UVA",
author = "Haibin Li and Linhao Li and Linhong Deng and Gurinder Singh and Tyrrell, \{Rex M.\} and Zhong, \{J. Li\}",
year = "2010",
doi = "10.1117/12.870980",
language = "英语",
isbn = "9780819483751",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optics in Health Care and Biomedical Optics IV",
note = "Optics in Health Care and Biomedical Optics IV ; Conference date: 18-10-2010 Through 20-10-2010",
}