A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Jun Deng; Yingying Tang; Qing Zhang; Chao Wang; Min Liao; Ping Ji; Jinlin Song; Gaoxing Luo; Luo Chen; Xiaohong Ran; Ziming Wei; Liwen Zheng; Ruyi Dang; Xiang Liu; Hongmei Zhang; Yu Shrike Zhang; Ximu Zhang; Hong Tan

doi:10.1002/adfm.201809110

A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Jun Deng
, Yingying Tang
, Qing Zhang
, Chao Wang
, Min Liao
, Ping Ji
, Jinlin Song
, Gaoxing Luo
, Luo Chen
, Xiaohong Ran
, Ziming Wei
, Liwen Zheng
, Ruyi Dang
, Xiang Liu
, Hongmei Zhang^*
, Yu Shrike Zhang
, Ximu Zhang
, Hong Tan

^*此作品的通讯作者

Chongqing Medical University
Children's Hospital of Chongqing Medical University
Brigham and Women’s Hospital
Sichuan University

科研成果: 期刊稿件 › 文章 › 同行评审

178 引用（Scopus）

摘要

Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

源语言	英语
文章编号	1809110
期刊	Advanced Functional Materials
卷	29
期	31
DOI	https://doi.org/10.1002/adfm.201809110
出版状态	已出版 - 1 8月 2019
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 7 经济适用的清洁能源

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Deng, J., Tang, Y., Zhang, Q., Wang, C., Liao, M., Ji, P., Song, J., Luo, G., Chen, L., Ran, X., Wei, Z., Zheng, L., Dang, R., Liu, X., Zhang, H., Zhang, Y. S., Zhang, X., & Tan, H. (2019). A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing. Advanced Functional Materials, 29(31), 文章 1809110. https://doi.org/10.1002/adfm.201809110

@article{b577659e008f46f7bb1502d2202984d9,

title = "A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing",

abstract = "Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.",

keywords = "Andrias davidianus, Chinese giant salamander, adhesive, hydrogel, wound healing",

author = "Jun Deng and Yingying Tang and Qing Zhang and Chao Wang and Min Liao and Ping Ji and Jinlin Song and Gaoxing Luo and Luo Chen and Xiaohong Ran and Ziming Wei and Liwen Zheng and Ruyi Dang and Xiang Liu and Hongmei Zhang and Zhang, \{Yu Shrike\} and Ximu Zhang and Hong Tan",

note = "Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = aug,

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doi = "10.1002/adfm.201809110",

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AU - Deng, Jun

AU - Tang, Yingying

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AU - Wang, Chao

AU - Liao, Min

AU - Ji, Ping

AU - Song, Jinlin

AU - Luo, Gaoxing

AU - Chen, Luo

AU - Ran, Xiaohong

AU - Wei, Ziming

AU - Zheng, Liwen

AU - Dang, Ruyi

AU - Liu, Xiang

AU - Zhang, Hongmei

AU - Zhang, Yu Shrike

AU - Zhang, Ximu

AU - Tan, Hong

PY - 2019/8/1

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N2 - Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

AB - Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

KW - Andrias davidianus

KW - Chinese giant salamander

KW - adhesive

KW - hydrogel

KW - wound healing

UR - https://www.scopus.com/pages/publications/85069940243

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DO - 10.1002/adfm.201809110

M3 - 文章

AN - SCOPUS:85069940243

SN - 1616-301X

VL - 29

JO - Advanced Functional Materials

JF - Advanced Functional Materials

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M1 - 1809110

ER -

A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

摘要

联合国可持续发展目标

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