3D Anatomical Structure-Guided Deep Learning for Accurate Diffusion Microstructure Imaging

Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require extensive diffusion gradient sampling, which can be time-consuming and limits the clinical applicability of tissue microstructure information. Recent advances in deep learning have shown promise in microstructure estimation; however, accurately estimating tissue microstructure from clinically feasible dMRI scans remains challenging without appropriate constraints. This paper introduces a novel framework that achieves high-fidelity and rapid diffusion microstructure imaging by simultaneously leveraging anatomical information from macro-level priors and mutual information across parameters. This approach enhances time efficiency while maintaining accuracy in microstructure estimation. Experimental results demonstrate that our method outperforms four state-of-the-art techniques, achieving a peak signal-to-noise ratio (PSNR) of 30.51±0.58 and a structural similarity index measure (SSIM) of 0.97±0.004 in estimating parametric maps of multiple diffusion models. Notably, our method achieves a 15× acceleration compared to the dense sampling approach, which typically utilizes 270 diffusion gradients.