精准医疗器械生/机接触界面功能化机制研究

The demand for medical and health care gradually increases with the development of society, and precision medicine with its advantages of low risk and precise customized treatment has attracted attention from global researchers. The precision medicine instruments come in various types, e.g. microscopic surgical tools and wearable sensors, which contact human tissues, cells and biological mucus during operation, and form bio-instrument contact interfaces with complicated physical/chemical properties. Due to the change of instrument types, operating environments and contact states, the bio-instrument contact interfaces have growing requirements in diverse functions, such as the securing fixation of wearable sensors and the anti-adhesion of electrical knives and electrocoagulation hooks. These bring up the common requirements of bio-instrument interface, i.e. the strong wet attachment and high-temperature anti-adhesion properties. Here, inspired by nature, we have studied the tree frog's toe pad (strong wet crawling) and Nepenthes alata peristome (ultra wet slippery at the oral edge) and extracted their material properties and microstructure characteristics. Their interfacial liquid adjusting rules have been revealed with the coupling effect of surface structure and materials, and the mechanism of strong wet friction and ultra-wet slippery have been established. Bioinspired strong wet friction surface and ultra-wet slipper surface have been designed and fabricated by combining the micro-nano fabrication processes, such as self-assembly and microstructure transfer etching. Finally, by applying bioinspired surfaces onto precision medical devices, and the tolerability of interfacial liquid volume of the bioinspired wearable sensor has been improved ~5 times compare to smooth surface, and the tissue adhesion on bioinspired surgical electrocoagulation is reduced by ~55%.