Typical application of skin diffusion optical model to quantitative description of tissue optical properties

Numerous publications have qualitatively indicated that the optical clearing technique by using biocompatible hyperosmotic agents could reduce the scattering effects within bio-tissue and further enhance the light to penetrate into it. However, few investigations have been carried out to quantitatively describe this effect and put it in use. In this talk, the permeation courses of biocompatible hyperosmotic agents into porcine skin tissue were simplified. A skin diffusion optical model was built to dynamically describe the courses of biocompatible hyperosmotic agents penetrating into skin, which was affected by the osmotic diffusivity of the model, and the changes of skin optical properties during the permeation courses. Meanwhile, experiments and skin Monte Carlo(MC) simulation studies were performed to investigate the optical clearing of porcine skin tissues medicated without and with biocompatible hyperosmotic agents. Both experimental and MC simulation results showed the availability of the diffusion model, which could quantitatively describe the change degree of optical property parameters with hyperosmotic agents immersing into different layers of skin. Therefore, the skin optical diffusion model would be potentially used to investigate how to quantitatively control the change of the optical property parameters of skin tissue topically applied with biocompatible hyperosmotic agents.