Two signals from B cells control the expansion of T cells: only one is immunologically specific

G. Parisi

doi:10.1016/0769-2625(88)90039-6

Two signals from B cells control the expansion of T cells: only one is immunologically specific

G. Parisi^*

^*Corresponding author for this work

University of Rome Tor Vergata

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Experimental data on thymidine incorporation by T cells as a function of the number of B cells and of the amount of antigen present on B cells are analysed.The data imply that T cells expand only after B cells deliver two signals. One signal is proportional to the antigen present on the surface of B cells and is immunologically specific; the other signal is independent of the antigen present on B cells and therefore is not immunologically specific.

Original language	English
Pages (from-to)	177-185
Number of pages	9
Journal	Annales de l'Institut Pasteur. Immunologie
Volume	139
Issue number	2
DOIs	https://doi.org/10.1016/0769-2625(88)90039-6
State	Published - 1988
Externally published	Yes

Keywords

Hypothèse
Immunorégulation
Immunospécificité
Lymphocyte B
Lymphocyte T
Signaux

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10.1016/0769-2625(88)90039-6

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abstract = "Experimental data on thymidine incorporation by T cells as a function of the number of B cells and of the amount of antigen present on B cells are analysed.The data imply that T cells expand only after B cells deliver two signals. One signal is proportional to the antigen present on the surface of B cells and is immunologically specific; the other signal is independent of the antigen present on B cells and therefore is not immunologically specific.",

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AB - Experimental data on thymidine incorporation by T cells as a function of the number of B cells and of the amount of antigen present on B cells are analysed.The data imply that T cells expand only after B cells deliver two signals. One signal is proportional to the antigen present on the surface of B cells and is immunologically specific; the other signal is independent of the antigen present on B cells and therefore is not immunologically specific.

KW - Hypothèse

KW - Immunorégulation

KW - Immunospécificité

KW - Lymphocyte B

KW - Lymphocyte T

KW - Signaux

UR - https://www.scopus.com/pages/publications/0023913295

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DO - 10.1016/0769-2625(88)90039-6

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AN - SCOPUS:0023913295

SN - 0769-2625

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JF - Annales de l'Institut Pasteur. Immunologie

IS - 2

ER -

Two signals from B cells control the expansion of T cells: only one is immunologically specific

Abstract

Keywords

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