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Three-Dimensional Radiopharmaceutical-Excited Fluorescence Imaging of Lymph Nodes

  • Northwest University China
  • CAS - Institute of Automation

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Optical imaging techniques have been developed for localizing lymph nodes before surgical resection due to the non-invasion and high sensitivity. However, its attendant penetrability limitations and auto-fluorescence effect have greatly limited the spatial resolution and imaging precision. In this study, a novel technique radiopharmaceutical-excited fluorescence imaging (REFI) was adopted to image lymph nodes, which use gamma-ray and Cerenkov radiation from radioisotopes to excite lanthanide europium oxide (EO) nanophosphors and boost the light intensity. An effective adaptive-steepest-descent-projection onto convex sets (ASD-POCS) reconstruction algorithm and the anatomic structure information were used to three-dimensionally image lymph nodes in mice models. The results indicate that REFI can greatly boost the light intensity and accuracy of threedimensional imaging of lymph node with location deviation less than 1.03 mm.

Original languageEnglish
Title of host publication2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538622827
DOIs
StatePublished - 12 Nov 2018
Externally publishedYes
Event2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Atlanta, United States
Duration: 21 Oct 201728 Oct 2017

Publication series

Name2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings

Conference

Conference2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017
Country/TerritoryUnited States
CityAtlanta
Period21/10/1728/10/17

Keywords

  • 3D reconstruction
  • lymph nodes imaging
  • radiopharmaceutical-excited fluorescence imaging

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