Abstract
Aim: This study aimed to develop indocyanine green- and doxorubicin-loaded liposomes (DILPs) as theranostic nanoplatform for the detection of hepatocellular carcinoma (HCC) and as an efficient chemotherapeutic to enhance microwave ablation. Materials & methods: DILPs were synthesized and thoroughly characterized. Biocompatibility, tumor uptake and accumulation, and synergistic ablation-chemotherapeutic efficiency were systematically explored in them. In addition, human HCC surgical samples were used to test the affinity of DILPs for HCC. Results: The combination of microwave ablation and DILPs enhanced the ablation efficiency of HCC with apparent tumor inhibition. DILPs exhibited excellent diagnostic ability and could detect 2.5-mm HCC lesions via optoacoustic tomography imaging. DILPs had better affinity for human HCC surgical samples compared with normal liver tissue. Conclusion: Theranostic DILPs could serve as promising nanoparticles for treatment and management of HCC in the clinic.
| Original language | English |
|---|---|
| Pages (from-to) | 2151-2167 |
| Number of pages | 17 |
| Journal | Nanomedicine |
| Volume | 14 |
| Issue number | 16 |
| DOIs | |
| State | Published - Aug 2019 |
| Externally published | Yes |
Keywords
- hepatocellular carcinoma
- liposomes
- microwave ablation
- optoacoustic tomography imaging
- theranostics
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