Abstract
A simple and stable method for the detection of cancer biomarker anterior gradient homolog 2 (AGR2) using UV–vis spectrometry is described. The sensing system is constructed easily with magnetic beads, aptamer, its complementary probe, and regular-shaped gold nanoparticles. The designed aptasensor exhibits excellent efficiency, selectivity and sensitivity toward AGR2 protein detection, and shows a picomolar range of detection limit. This extraordinary performance can be attributed to the effective separation of magnetic beads, the highly selective Gquadruplex formation of AGR2 proteins recognized by aptamers, the unique optical properties of gold nanoparticles and the special sandwich structure of the aptasensor.
| Original language | English |
|---|---|
| Pages (from-to) | 846-852 |
| Number of pages | 7 |
| Journal | Sensors and Actuators B: Chemical |
| Volume | 209 |
| DOIs | |
| State | Published - 1 Mar 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- AGR2
- Aptasensor
- Gold nanoparticles
- Magnetic beads
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