The Probe-combined Microspheres Applied in Biomedical Field for Super-resolution Imagings and Micromanipulations

  • Shilin Gao
  • , Kai Meng
  • , Zhan Yang
  • , Huicong Liu
  • , Fengxia Wang
  • , Lining Sun
  • , Tao Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Because of the optical diffraction limit, standard optical microscopies are not suitable to directly observe the biological samples with the small size between 5 to 150 nm. It has been experimentally demonstrated that microspheres have the ability of super-resolution imaging. Here, we report a probe-combined microsphere which consists of a barium titanate microsphere with the diameter of 50 sim 100 mu m and a probe. The finite element method is performed by the COMSOL Multiphysics software to confirm that the probe has no influence on the microsphere imaging. When the probe-combined microsphere was installed on a three-dimensional precision translation stage, it can be moved to the desirable area to capture the tiny feature of rat liver slices and the appearance of cells. What's more, the probe-combined microsphere can adsorb the cells on the back of the microsphere, and thus it can be used as a tool to pick up cells. Another probe can operate the cells and morphological changes of cells can be observed through the microsphere at the same time.

Original languageEnglish
Title of host publication2019 4th Asia-Pacific Conference on Intelligent Robot Systems, ACIRS 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages155-158
Number of pages4
ISBN (Electronic)9781728122298
DOIs
StatePublished - Jul 2019
Externally publishedYes
Event4th Asia-Pacific Conference on Intelligent Robot Systems, ACIRS 2019 - Nagoya, Japan
Duration: 13 Jul 201915 Jul 2019

Publication series

Name2019 4th Asia-Pacific Conference on Intelligent Robot Systems, ACIRS 2019

Conference

Conference4th Asia-Pacific Conference on Intelligent Robot Systems, ACIRS 2019
Country/TerritoryJapan
CityNagoya
Period13/07/1915/07/19

Keywords

  • biomedical
  • imaging
  • micromanipulation
  • probe-combined microsphere

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