The Effect of TiAl6V4 Particles on Tissue in Rats

Electron beam melting (EBM) is three-dimensional (3D) printing technologies that can manufacture multi-functional porous scaffolds with exact structures for the application of surgical operations. In the past decade, thousands of acetabular implants manufactured by EBM or SLM have been designed into acetabular cups with certain porosity for surgical operations. Particles of 3D printed porous Ti6Al4V implants will adhere between sintered interface and non-sintered interface of porous sample during 3D printing. However, the internal excess particles of complex structural parts are difficult to remove. During long-term cyclic loading, stress strain can cause residual Ti6Al4V particles to fall off. These detached Ti6Al4V particles are scattered around the implant and are contact with osteoblasts. In our study, we detected the influence of the differentiation concentration of Ti6Al4V particles on bone of rats. The influence of the differentiation concentration of Ti6Al4V particles on bone was evaluated by distal femoral defects in rats. Micro-CT and biochemical analysis were used to evaluate all of the rats after 12 weeks. Outcomes demonstrated that low concentration Ti6Al4V particles may improve the osteogenesis of SD rat through micro-CT. Serum markers implied that the differentiation concentration of Ti6Al4V particles didn't influence on hepatic and renal functions. In conclusion, Low-dose residual particle does not induce a decrease in bone mineral density (BMD) of rats.