Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems

Zhenglong Yang; Xinyan Liu; Xiaoli Xu; Sai Chen; Xingyi Zhu; Yuchuan Du; Feng Li

doi:10.1016/j.matchemphys.2016.05.010

Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems

Zhenglong Yang^*
, Xinyan Liu
, Xiaoli Xu
, Sai Chen
, Xingyi Zhu
, Yuchuan Du
, Feng Li

^*Corresponding author for this work

Tongji University
Ministry of Transport of the People's Republic of China

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of thiol-ene click chemistry and reversible addition fragmentation chain transfer polymerization. Their structures and self-assembly behaviors were characterized via ¹H NMR, TEM, UV-vis and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. In vitro drug release behavior of POSS/PDMAEMA-b-PNIPAM micelles loading camptothecin indicated that the rate of drug release could be effectively controlled by altering the temperature and pH values of the environment. As 80% of the camptothecin drug was released at pH 5.5 or temperature of 45 °C within 35 h, the excellent thermo- and pH-response ability of POSS/PDMAME-b-PNIPAM micelles makes them desirable candidates for controlled drug delivery systems.

Original language	English
Pages (from-to)	65-71
Number of pages	7
Journal	Materials Chemistry and Physics
Volume	179
DOIs	https://doi.org/10.1016/j.matchemphys.2016.05.010
State	Published - 15 Aug 2016
Externally published	Yes

Keywords

Chemical synthesis
Critical phenomena
Inorganic compounds
Polymers

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Yang, Z., Liu, X., Xu, X., Chen, S., Zhu, X., Du, Y., & Li, F. (2016). Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems. Materials Chemistry and Physics, 179, 65-71. https://doi.org/10.1016/j.matchemphys.2016.05.010

Yang, Zhenglong ; Liu, Xinyan ; Xu, Xiaoli et al. / Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction : Potential candidates as drug delivery systems. In: Materials Chemistry and Physics. 2016 ; Vol. 179. pp. 65-71.

@article{36682cbac50a4ecabc432c724b04bbda,

title = "Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems",

abstract = "The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of thiol-ene click chemistry and reversible addition fragmentation chain transfer polymerization. Their structures and self-assembly behaviors were characterized via 1H NMR, TEM, UV-vis and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. In vitro drug release behavior of POSS/PDMAEMA-b-PNIPAM micelles loading camptothecin indicated that the rate of drug release could be effectively controlled by altering the temperature and pH values of the environment. As 80\% of the camptothecin drug was released at pH 5.5 or temperature of 45 °C within 35 h, the excellent thermo- and pH-response ability of POSS/PDMAME-b-PNIPAM micelles makes them desirable candidates for controlled drug delivery systems.",

keywords = "Chemical synthesis, Critical phenomena, Inorganic compounds, Polymers",

author = "Zhenglong Yang and Xinyan Liu and Xiaoli Xu and Sai Chen and Xingyi Zhu and Yuchuan Du and Feng Li",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2016",

month = aug,

day = "15",

doi = "10.1016/j.matchemphys.2016.05.010",

language = "英语",

volume = "179",

pages = "65--71",

journal = "Materials Chemistry and Physics",

issn = "0254-0584",

publisher = "Elsevier B.V.",

}

Yang, Z, Liu, X, Xu, X, Chen, S, Zhu, X, Du, Y & Li, F 2016, 'Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems', Materials Chemistry and Physics, vol. 179, pp. 65-71. https://doi.org/10.1016/j.matchemphys.2016.05.010

Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems. / Yang, Zhenglong; Liu, Xinyan; Xu, Xiaoli et al.
In: Materials Chemistry and Physics, Vol. 179, 15.08.2016, p. 65-71.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction

T2 - Potential candidates as drug delivery systems

AU - Yang, Zhenglong

AU - Liu, Xinyan

AU - Xu, Xiaoli

AU - Chen, Sai

AU - Zhu, Xingyi

AU - Du, Yuchuan

AU - Li, Feng

PY - 2016/8/15

Y1 - 2016/8/15

N2 - The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of thiol-ene click chemistry and reversible addition fragmentation chain transfer polymerization. Their structures and self-assembly behaviors were characterized via 1H NMR, TEM, UV-vis and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. In vitro drug release behavior of POSS/PDMAEMA-b-PNIPAM micelles loading camptothecin indicated that the rate of drug release could be effectively controlled by altering the temperature and pH values of the environment. As 80% of the camptothecin drug was released at pH 5.5 or temperature of 45 °C within 35 h, the excellent thermo- and pH-response ability of POSS/PDMAME-b-PNIPAM micelles makes them desirable candidates for controlled drug delivery systems.

AB - The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of thiol-ene click chemistry and reversible addition fragmentation chain transfer polymerization. Their structures and self-assembly behaviors were characterized via 1H NMR, TEM, UV-vis and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. In vitro drug release behavior of POSS/PDMAEMA-b-PNIPAM micelles loading camptothecin indicated that the rate of drug release could be effectively controlled by altering the temperature and pH values of the environment. As 80% of the camptothecin drug was released at pH 5.5 or temperature of 45 °C within 35 h, the excellent thermo- and pH-response ability of POSS/PDMAME-b-PNIPAM micelles makes them desirable candidates for controlled drug delivery systems.

KW - Chemical synthesis

KW - Critical phenomena

KW - Inorganic compounds

KW - Polymers

UR - https://www.scopus.com/pages/publications/84966746447

U2 - 10.1016/j.matchemphys.2016.05.010

DO - 10.1016/j.matchemphys.2016.05.010

M3 - 文章

AN - SCOPUS:84966746447

SN - 0254-0584

VL - 179

SP - 65

EP - 71

JO - Materials Chemistry and Physics

JF - Materials Chemistry and Physics

ER -

Yang Z, Liu X, Xu X, Chen S, Zhu X, Du Y et al. Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems. Materials Chemistry and Physics. 2016 Aug 15;179:65-71. doi: 10.1016/j.matchemphys.2016.05.010

Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems

Abstract

Keywords

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