TY - GEN
T1 - Study on the weakest interaction model for chiral resolution using molecularly imprinted polymer
AU - Rong, Fei
AU - Li, Ping
PY - 2012
Y1 - 2012
N2 - Molecularly imprinted polymers (MIPs) of L-phenylalanine ethyl ester were synthesized in this study. Then, the prepared MIPs were packed in a stainless column and evaluated as the chiral stationary phases of high performance liquid chromatography (HPLC). The MIPs exhibited a considerable capability of chiral separation between template molecule and its enantiomer with the separation factor of 1.69. Furthermore, the weakest interaction model was introduced to study the chiral recognition mechanism of MIPs. The results suggested that the weakest interaction between the template molecule and the imprinted cavity played crucial role in chiral separation, and the molecular tension should be taken into consideration during the separation procedure. The separation factor of 2.07 was calculated by the theoretical model, which was very close to the value obtained from chromatographic experiment.
AB - Molecularly imprinted polymers (MIPs) of L-phenylalanine ethyl ester were synthesized in this study. Then, the prepared MIPs were packed in a stainless column and evaluated as the chiral stationary phases of high performance liquid chromatography (HPLC). The MIPs exhibited a considerable capability of chiral separation between template molecule and its enantiomer with the separation factor of 1.69. Furthermore, the weakest interaction model was introduced to study the chiral recognition mechanism of MIPs. The results suggested that the weakest interaction between the template molecule and the imprinted cavity played crucial role in chiral separation, and the molecular tension should be taken into consideration during the separation procedure. The separation factor of 2.07 was calculated by the theoretical model, which was very close to the value obtained from chromatographic experiment.
KW - Molecular tension
KW - Molecularly imprinted polymers
KW - Thermodynamics
KW - Weakest interaction model
UR - https://www.scopus.com/pages/publications/84455173824
U2 - 10.4028/www.scientific.net/AMR.391-392.111
DO - 10.4028/www.scientific.net/AMR.391-392.111
M3 - 会议稿件
AN - SCOPUS:84455173824
SN - 9783037853337
T3 - Advanced Materials Research
SP - 111
EP - 115
BT - Chemical Engineering and Material Properties
T2 - 2011 International Symposium on Chemical Engineering and Material Properties, ISCEMP 2011
Y2 - 4 November 2011 through 6 November 2011
ER -