Structure correction for robust volume segmentation in presence of tumors

CNN based lung segmentation models in absence of diverse training dataset fail to segment lung volumes in presence of severe pathologies such as large masses, scars, and tumors. To rectify this problem, we propose a multi-stage algorithm for lung volume segmentation from CT scans. The algorithm uses a 3D CNN in the first stage to obtain a coarse segmentation of the left and right lungs. In the second stage, shape correction is performed on the segmentation mask using a 3D structure correction CNN. A novel data augmentation strategy is adopted to train a 3D CNN which helps in incorporating global shape prior. Finally, the shape corrected segmentation mask is up-sampled and refined using a parallel flood-fill operation. The proposed multi-stage algorithm is robust in the presence of large nodules/tumors and does not require labeled segmentation masks for entire pathological lung volume for training. Through extensive experiments conducted on publicly available datasets such as NSCLC, LUNA, and LOLA11 we demonstrate that the proposed approach improves the recall of large juxtapleural tumor voxels by at least 15% over state-of-the-art models without sacrificing segmentation accuracy in case of normal lungs. The proposed method also meets the requirement of CAD software by performing segmentation within 5 seconds which is significantly faster than present methods.