Simultaneous Imaging of Magnetic Nanoparticle Concentration, Temperature, and Viscosity

In the coming era of precision medicine, there is a high demand for the development of approaches for in vivo tracking of biomolecules and measurements of their local environments. In this work, we present an approach for the simultaneous imaging of magnetic nanoparticle (MNP) concentration, temperature, and viscosity. The proposed approach allows one to determine the spatial distribution of the MNPs, while the MNPs are used as nanosensors for simultaneous measurements of the spatial distributions of temperature and viscosity. This technique has great potential for providing not only tools for disease diagnostics and therapy, but also insights into further understanding of the biophysical mechanisms involved in tumor tissues during cancer development and tumor metastasis.