Silicon nanowire-based methodology for quantifying single cell traction force

Y. S. Niu; L. Yan; M. Dai; X. Li; S. Y. Feng; F. Xue; Y. B. Fan; Z. Li

doi:10.1007/978-3-642-29305-4_76

Silicon nanowire-based methodology for quantifying single cell traction force

Y. S. Niu
, L. Yan
, M. Dai
, X. Li
, S. Y. Feng
, F. Xue
, Y. B. Fan^*
, Z. Li

^*Corresponding author for this work

Beihang University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this paper, we present a new method, a siliconnanowire- array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite Element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering
Pages	282-285
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-642-29305-4_76
State	Published - 2013
Event	World Congress on Medical Physics and Biomedical Engineering - Beijing, China Duration: 26 May 2012 → 31 May 2012

Publication series

Name	IFMBE Proceedings
Volume	39 IFMBE
ISSN (Print)	1680-0737

Conference

Conference	World Congress on Medical Physics and Biomedical Engineering
Country/Territory	China
City	Beijing
Period	26/05/12 → 31/05/12

Keywords

Cell Traction Force
Cellular Mechanical Properties
Finite Element Simulation
Silicon Nanowire Array

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10.1007/978-3-642-29305-4_76

Cite this

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title = "Silicon nanowire-based methodology for quantifying single cell traction force",

abstract = "In this paper, we present a new method, a siliconnanowire- array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite Element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.",

keywords = "Cell Traction Force, Cellular Mechanical Properties, Finite Element Simulation, Silicon Nanowire Array",

author = "Niu, \{Y. S.\} and L. Yan and M. Dai and X. Li and Feng, \{S. Y.\} and F. Xue and Fan, \{Y. B.\} and Z. Li",

year = "2013",

doi = "10.1007/978-3-642-29305-4\_76",

language = "英语",

isbn = "9783642293047",

series = "IFMBE Proceedings",

pages = "282--285",

booktitle = "World Congress on Medical Physics and Biomedical Engineering",

note = "World Congress on Medical Physics and Biomedical Engineering ; Conference date: 26-05-2012 Through 31-05-2012",

}

Niu, YS, Yan, L, Dai, M, Li, X, Feng, SY, Xue, F, Fan, YB & Li, Z 2013, Silicon nanowire-based methodology for quantifying single cell traction force. in World Congress on Medical Physics and Biomedical Engineering. IFMBE Proceedings, vol. 39 IFMBE, pp. 282-285, World Congress on Medical Physics and Biomedical Engineering, Beijing, China, 26/05/12. https://doi.org/10.1007/978-3-642-29305-4_76

TY - GEN

T1 - Silicon nanowire-based methodology for quantifying single cell traction force

AU - Niu, Y. S.

AU - Yan, L.

AU - Dai, M.

AU - Li, X.

AU - Feng, S. Y.

AU - Xue, F.

AU - Fan, Y. B.

AU - Li, Z.

PY - 2013

Y1 - 2013

N2 - In this paper, we present a new method, a siliconnanowire- array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite Element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.

AB - In this paper, we present a new method, a siliconnanowire- array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite Element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.

KW - Cell Traction Force

KW - Cellular Mechanical Properties

KW - Finite Element Simulation

KW - Silicon Nanowire Array

UR - https://www.scopus.com/pages/publications/84876037958

U2 - 10.1007/978-3-642-29305-4_76

DO - 10.1007/978-3-642-29305-4_76

M3 - 会议稿件

AN - SCOPUS:84876037958

SN - 9783642293047

T3 - IFMBE Proceedings

SP - 282

EP - 285

BT - World Congress on Medical Physics and Biomedical Engineering

T2 - World Congress on Medical Physics and Biomedical Engineering

Y2 - 26 May 2012 through 31 May 2012

ER -

Silicon nanowire-based methodology for quantifying single cell traction force

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Keywords

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