Abstract
This work investigates the influence of cytophilic and anisotropic nanomaterials on accelerated cell attachment and directional migration toward rapid wound healing. Inspired by the anisotropic protein nanofibers in scab, a polyurethane (PU) nanofibrous membrane with an aligned structure was fabricated. The membrane showed good affinity for wound-healing-related cells and could guide cell migration in the direction of PU nanofibers. Also, the morphology and distribution of F-actin and paxillin of attached cells were influenced by the underlying nanofibers. The randomly distributed PU nanofibers and planar PU membrane did not show a distinct impact on cell migration. This scab-inspired cytophilic membrane is promising in applications as functional interfacial biomaterials for rapid wound healing, bone repair, and construction of neural networks.
| Original language | English |
|---|---|
| Pages (from-to) | 4821-4826 |
| Number of pages | 6 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| State | Published - 12 Jun 2013 |
| Externally published | Yes |
Keywords
- anisotropic nanofibrous membranes
- cell attachment
- cell migration
- cytophilic
- wound healing
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