TY - GEN
T1 - Research on a Resonance Spectrum-Based Method for Measuring the Elastic Modulus of Small Size Soft Tissue Samples
AU - Hu, Yujie
AU - Lu, Kecai
AU - Shen, Fei
AU - Fan, Fan
AU - Wang, Yue
AU - Li, Fengji
AU - Niu, Haijun
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - The elastic properties of biological tissues are highly correlated with pathological states. Accurate measurement of tissue elasticity can offer crucial insights for early disease diagnosis and precise treatment. This study introduces a method for measuring the elastic modulus of small size soft tissue samples. We utilize a surface microbead driven by external magnetic field as the excitation source, combined with resonance spectrum measurement based on optical coherence tomography (OCT), to obtain the tissue resonance frequency under microbead excitation. This study reveals significant linear correlation (R2=0.9994) between the resonance frequency of various component phantom materials (0.5%, 0.75%, 1.0%, 1.25%, 1.5%) - respectively 118.5±3.7 Hz, 200.8±2.9 Hz, 280.0±5.2 Hz, 360.9±6.8 Hz, 431.1±6.5 Hz - and the square root of the Young's modulus. Moreover, the measured resonance frequency is unaffected by the amplitude of the magnetic excitation or the measurement location on the sample. This study provides an effective and robust way to obtain the elastic modulus of soft tissue materials.
AB - The elastic properties of biological tissues are highly correlated with pathological states. Accurate measurement of tissue elasticity can offer crucial insights for early disease diagnosis and precise treatment. This study introduces a method for measuring the elastic modulus of small size soft tissue samples. We utilize a surface microbead driven by external magnetic field as the excitation source, combined with resonance spectrum measurement based on optical coherence tomography (OCT), to obtain the tissue resonance frequency under microbead excitation. This study reveals significant linear correlation (R2=0.9994) between the resonance frequency of various component phantom materials (0.5%, 0.75%, 1.0%, 1.25%, 1.5%) - respectively 118.5±3.7 Hz, 200.8±2.9 Hz, 280.0±5.2 Hz, 360.9±6.8 Hz, 431.1±6.5 Hz - and the square root of the Young's modulus. Moreover, the measured resonance frequency is unaffected by the amplitude of the magnetic excitation or the measurement location on the sample. This study provides an effective and robust way to obtain the elastic modulus of soft tissue materials.
KW - Elasticity Measurement
KW - Optical Coherence Tomography
KW - Resonance Spectrum
KW - Soft Tissue
UR - https://www.scopus.com/pages/publications/85214999913
U2 - 10.1109/EMBC53108.2024.10782683
DO - 10.1109/EMBC53108.2024.10782683
M3 - 会议稿件
C2 - 40038958
AN - SCOPUS:85214999913
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
BT - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024
Y2 - 15 July 2024 through 19 July 2024
ER -