TY - JOUR
T1 - Radioactive Beams for Image-Guided Particle Therapy
T2 - The BARB Experiment at GSI
AU - the Super-FRS Experiment Collaboration
AU - Boscolo, Daria
AU - Kostyleva, Daria
AU - Safari, Mohammad Javad
AU - Anagnostatou, Vasiliki
AU - Äystö, Juha
AU - Bagchi, Soumya
AU - Binder, Tim
AU - Dedes, Georgios
AU - Dendooven, Peter
AU - Dickel, Timo
AU - Drozd, Vasyl
AU - Franczack, Bernhard
AU - Geissel, Hans
AU - Gianoli, Chiara
AU - Graeff, Christian
AU - Grahn, Tuomas
AU - Greiner, Florian
AU - Haettner, Emma
AU - Haghani, Roghieh
AU - Harakeh, Muhsin N.
AU - Horst, Felix
AU - Hornung, Christine
AU - Hucka, Jan Paul
AU - Kalantar-Nayestanaki, Nasser
AU - Kazantseva, Erika
AU - Kindler, Birgit
AU - Knöbel, Ronja
AU - Kuzminchuk-Feuerstein, Natalia
AU - Lommel, Bettina
AU - Mukha, Ivan
AU - Nociforo, Chiara
AU - Ishikawa, Shunki
AU - Lovatti, Giulio
AU - Nitta, Munetaka
AU - Ozoemelam, Ikechi
AU - Pietri, Stephane
AU - Plaß, Wolfgang R.
AU - Prochazka, Andrej
AU - Purushothaman, Sivaji
AU - Reidel, Claire Anne
AU - Roesch, Heidi
AU - Schirru, Fabio
AU - Schuy, Christoph
AU - Sokol, Olga
AU - Steinsberger, Timo
AU - Tanaka, Yoshiki K.
AU - Tanihata, Isao
AU - Thirolf, Peter
AU - Tinganelli, Walter
AU - Voss, Bernd
N1 - Publisher Copyright:
© Copyright © 2021 Boscolo, Kostyleva, Safari, Anagnostatou, Äystö, Bagchi, Binder, Dedes, Dendooven, Dickel, Drozd, Franczack, Geissel, Gianoli, Graeff, Grahn, Greiner, Haettner, Haghani, Harakeh, Horst, Hornung, Hucka, Kalantar-Nayestanaki, Kazantseva, Kindler, Knöbel, Kuzminchuk-Feuerstein, Lommel, Mukha, Nociforo, Ishikawa, Lovatti, Nitta, Ozoemelam, Pietri, Plaß, Prochazka, Purushothaman, Reidel, Roesch, Schirru, Schuy, Sokol, Steinsberger, Tanaka, Tanihata, Thirolf, Tinganelli, Voss, Weber, Weick, Winfield, Winkler, Zhao, Scheidenberger, Parodi, Durante and the Super-FRS Experiment Collaboration.
PY - 2021/8/19
Y1 - 2021/8/19
N2 - Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.
AB - Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.
KW - PET
KW - carbon ions
KW - oxygen ions
KW - particle therapy
KW - radioactive ion beams
UR - https://www.scopus.com/pages/publications/85114647419
U2 - 10.3389/fonc.2021.737050
DO - 10.3389/fonc.2021.737050
M3 - 文章
AN - SCOPUS:85114647419
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 737050
ER -
SDG 3 Good Health and Well-being