Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling

Han Gong; Xin Xu; Zuliyaer Talifu; Chun Jia Zhang; Yu Zhe Sun; Zhao Ming Yue; Jia Sheng Rao; Liang Jie Du; Xiao Xia Du

doi:10.1016/j.reth.2025.03.008

Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling

Han Gong
, Xin Xu
, Zuliyaer Talifu
, Chun Jia Zhang
, Yu Zhe Sun
, Zhao Ming Yue
, Jia Sheng Rao^*
, Liang Jie Du^*
, Xiao Xia Du^*

^*Corresponding author for this work

School of Biological Science and Medical Engineering

Beihang University
University of Health and Rehabilitation Sciences
Capital Medical University
China Disabled Persons' Federation
Shandong University
Qilu Hospital of Shandong University
Chinese Academy of Medical Sciences
Peking University

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory synaptic transmission in the central nervous system, contributing to various physiological and pathological functions including learning, memory, neural development, synaptic transmission, and plasticity. NMDAR signaling plays a role in spinal cord injury outcomes, including restoring spinal circuits, modulating synaptic plasticity, reinstating synchronized functions, enhancing motor capabilities, and reducing neuropathic pain. Consequently, targeting NMDARs may serve as a promising approach to enhance axonal regeneration and reorganization of neural circuits following spinal injury.

Original language	English
Pages (from-to)	381-389
Number of pages	9
Journal	Regenerative Therapy
Volume	29
DOIs	https://doi.org/10.1016/j.reth.2025.03.008
State	Published - Jun 2025

Keywords

Long-term potentiation
N-methyl-D-aspartate receptors
Neural plasticity
Spinal cord injury

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10.1016/j.reth.2025.03.008

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title = "Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling",

abstract = "N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory synaptic transmission in the central nervous system, contributing to various physiological and pathological functions including learning, memory, neural development, synaptic transmission, and plasticity. NMDAR signaling plays a role in spinal cord injury outcomes, including restoring spinal circuits, modulating synaptic plasticity, reinstating synchronized functions, enhancing motor capabilities, and reducing neuropathic pain. Consequently, targeting NMDARs may serve as a promising approach to enhance axonal regeneration and reorganization of neural circuits following spinal injury.",

keywords = "Long-term potentiation, N-methyl-D-aspartate receptors, Neural plasticity, Spinal cord injury",

author = "Han Gong and Xin Xu and Zuliyaer Talifu and Zhang, \{Chun Jia\} and Sun, \{Yu Zhe\} and Yue, \{Zhao Ming\} and Rao, \{Jia Sheng\} and Du, \{Liang Jie\} and Du, \{Xiao Xia\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s)",

year = "2025",

month = jun,

doi = "10.1016/j.reth.2025.03.008",

language = "英语",

volume = "29",

pages = "381--389",

journal = "Regenerative Therapy",

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publisher = "Japanese Society of Regenerative Medicine",

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TY - JOUR

T1 - Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling

AU - Gong, Han

AU - Xu, Xin

AU - Talifu, Zuliyaer

AU - Zhang, Chun Jia

AU - Sun, Yu Zhe

AU - Yue, Zhao Ming

AU - Rao, Jia Sheng

AU - Du, Liang Jie

AU - Du, Xiao Xia

PY - 2025/6

Y1 - 2025/6

N2 - N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory synaptic transmission in the central nervous system, contributing to various physiological and pathological functions including learning, memory, neural development, synaptic transmission, and plasticity. NMDAR signaling plays a role in spinal cord injury outcomes, including restoring spinal circuits, modulating synaptic plasticity, reinstating synchronized functions, enhancing motor capabilities, and reducing neuropathic pain. Consequently, targeting NMDARs may serve as a promising approach to enhance axonal regeneration and reorganization of neural circuits following spinal injury.

AB - N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory synaptic transmission in the central nervous system, contributing to various physiological and pathological functions including learning, memory, neural development, synaptic transmission, and plasticity. NMDAR signaling plays a role in spinal cord injury outcomes, including restoring spinal circuits, modulating synaptic plasticity, reinstating synchronized functions, enhancing motor capabilities, and reducing neuropathic pain. Consequently, targeting NMDARs may serve as a promising approach to enhance axonal regeneration and reorganization of neural circuits following spinal injury.

KW - Long-term potentiation

KW - N-methyl-D-aspartate receptors

KW - Neural plasticity

KW - Spinal cord injury

UR - https://www.scopus.com/pages/publications/105002024052

U2 - 10.1016/j.reth.2025.03.008

DO - 10.1016/j.reth.2025.03.008

M3 - 文献综述

AN - SCOPUS:105002024052

SN - 2352-3204

VL - 29

SP - 381

EP - 389

JO - Regenerative Therapy

JF - Regenerative Therapy

ER -

Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling

Abstract

Keywords

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