Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Weifeng Lin; Nir Kampf; Ronit Goldberg; Michael J. Driver; Jacob Klein

doi:10.1021/acs.langmuir.9b00610

Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Weifeng Lin
, Nir Kampf
, Ronit Goldberg
, Michael J. Driver
, Jacob Klein^*

^*Corresponding author for this work

Weizmann Institute of Science
Vertellus Specialties Inc.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined as coefficient of friction μ < 10 ^-2 ) via hydration lubrication at physiological salt concentrations and pressures. In contrast, vesicles sterically protected by poly(ethylene glycol) chains (PEGylation), which is the general method of choice, while being equally stable to aggregation are much poorer lubricants under these conditions, which is attributed to the relatively poor hydration of the PEG. Our approach enables the use of PC liposomes as stable superlubrication vectors in potential biomedical applications.

Original language	English
Pages (from-to)	6048-6054
Number of pages	7
Journal	Langmuir
Volume	35
Issue number	18
DOIs	https://doi.org/10.1021/acs.langmuir.9b00610
State	Published - 7 May 2019
Externally published	Yes

Access to Document

10.1021/acs.langmuir.9b00610

Cite this

@article{e669b5b153cf4d8db531ffbef2538b8c,

title = "Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors",

abstract = " We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined as coefficient of friction μ < 10 -2 ) via hydration lubrication at physiological salt concentrations and pressures. In contrast, vesicles sterically protected by poly(ethylene glycol) chains (PEGylation), which is the general method of choice, while being equally stable to aggregation are much poorer lubricants under these conditions, which is attributed to the relatively poor hydration of the PEG. Our approach enables the use of PC liposomes as stable superlubrication vectors in potential biomedical applications.",

author = "Weifeng Lin and Nir Kampf and Ronit Goldberg and Driver, \{Michael J.\} and Jacob Klein",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = may,

day = "7",

doi = "10.1021/acs.langmuir.9b00610",

language = "英语",

volume = "35",

pages = "6048--6054",

journal = "Langmuir",

issn = "0743-7463",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

AU - Lin, Weifeng

AU - Kampf, Nir

AU - Goldberg, Ronit

AU - Driver, Michael J.

AU - Klein, Jacob

PY - 2019/5/7

Y1 - 2019/5/7

N2 - We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined as coefficient of friction μ < 10 -2 ) via hydration lubrication at physiological salt concentrations and pressures. In contrast, vesicles sterically protected by poly(ethylene glycol) chains (PEGylation), which is the general method of choice, while being equally stable to aggregation are much poorer lubricants under these conditions, which is attributed to the relatively poor hydration of the PEG. Our approach enables the use of PC liposomes as stable superlubrication vectors in potential biomedical applications.

AB - We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric performance (defined as coefficient of friction μ < 10 -2 ) via hydration lubrication at physiological salt concentrations and pressures. In contrast, vesicles sterically protected by poly(ethylene glycol) chains (PEGylation), which is the general method of choice, while being equally stable to aggregation are much poorer lubricants under these conditions, which is attributed to the relatively poor hydration of the PEG. Our approach enables the use of PC liposomes as stable superlubrication vectors in potential biomedical applications.

UR - https://www.scopus.com/pages/publications/85065445711

U2 - 10.1021/acs.langmuir.9b00610

DO - 10.1021/acs.langmuir.9b00610

M3 - 文章

C2 - 30991806

AN - SCOPUS:85065445711

SN - 0743-7463

VL - 35

SP - 6048

EP - 6054

JO - Langmuir

JF - Langmuir

IS - 18

ER -

Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors

Abstract

Access to Document

Other files and links

Fingerprint

Cite this