Pkweb: An online application for pharmacokinetic data analysis

Zhaomin Dong; Xiarui Fan; Wenhong Fan; Hong Chang; Yilu Xu; Tong Li; Ming Su

doi:10.1016/j.eti.2020.100838

Pkweb: An online application for pharmacokinetic data analysis

Zhaomin Dong
, Xiarui Fan
, Wenhong Fan
, Hong Chang
, Yilu Xu^*
, Tong Li
, Ming Su

^*Corresponding author for this work

School of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis.

Original language	English
Article number	100838
Journal	Environmental Technology and Innovation
Volume	19
DOIs	https://doi.org/10.1016/j.eti.2020.100838
State	Published - Aug 2020

Keywords

Online application
Pharmacokinetic
Pkweb
Prior parameters
R shiny

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10.1016/j.eti.2020.100838

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title = "Pkweb: An online application for pharmacokinetic data analysis",

abstract = "This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis.",

keywords = "Online application, Pharmacokinetic, Pkweb, Prior parameters, R shiny",

author = "Zhaomin Dong and Xiarui Fan and Wenhong Fan and Hong Chang and Yilu Xu and Tong Li and Ming Su",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = aug,

doi = "10.1016/j.eti.2020.100838",

language = "英语",

volume = "19",

journal = "Environmental Technology and Innovation",

issn = "2352-1864",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Pkweb

T2 - An online application for pharmacokinetic data analysis

AU - Dong, Zhaomin

AU - Fan, Xiarui

AU - Fan, Wenhong

AU - Chang, Hong

AU - Xu, Yilu

AU - Li, Tong

AU - Su, Ming

PY - 2020/8

Y1 - 2020/8

N2 - This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis.

AB - This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis.

KW - Online application

KW - Pharmacokinetic

KW - Pkweb

KW - Prior parameters

KW - R shiny

UR - https://www.scopus.com/pages/publications/85084743640

U2 - 10.1016/j.eti.2020.100838

DO - 10.1016/j.eti.2020.100838

M3 - 文章

AN - SCOPUS:85084743640

SN - 2352-1864

VL - 19

JO - Environmental Technology and Innovation

JF - Environmental Technology and Innovation

M1 - 100838

ER -

Pkweb: An online application for pharmacokinetic data analysis

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Keywords

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