Photoredox Fe-Catalyzed Truce–Smiles Rearrangement of N-Arylsulfonyl Acrylamides with Aliphatic Carboxylic Acids

Herein, we report a photoredox Fe-catalyzed, redox-neutral Truce–Smiles rearrangement of N-arylsulfonyl acrylamides using readily available aliphatic carboxylic acids as radical precursors. This method accommodates a broad range of alkyl carboxylic acids, including difluoroacetic acid, enabling efficient access to functionalized amides that can be readily transformed into valuable CF₂H-containing arylethylamines. The catalytic system is amenable to gram-scale synthesis, and mechanistic investigations support a radical-mediated mechanism involving intramolecular aryl migration.