Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats

Wei Zhang; Xin Bin Zhao; Hong Yang; Min Ni

doi:10.3724/SP.J.1008.2012.001315

Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats

Wei Zhang
, Xin Bin Zhao
, Hong Yang
, Min Ni^*

^*Corresponding author for this work

PLA
The Second Military Medical University

Research output: Contribution to journal › Article › peer-review

Abstract

Objective To determine the role of different molecular compositions of K^ATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. Methods SAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective K^ATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). Results Both pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. Conclusion Opening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.

Original language	English
Pages (from-to)	1315-1318
Number of pages	4
Journal	Academic Journal of Second Military Medical University
Volume	33
Issue number	12
DOIs	https://doi.org/10.3724/SP.J.1008.2012.001315
State	Published - 2012
Externally published	Yes

Keywords

Blood pressure variability
Sinoaortic denervated
Vascular smooth muscle

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10.3724/SP.J.1008.2012.001315

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@article{b95c970505974bff90b63189a12740f1,

title = "Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats",

abstract = "Objective To determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. Methods SAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). Results Both pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. Conclusion Opening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.",

keywords = "Blood pressure variability, Sinoaortic denervated, Vascular smooth muscle",

author = "Wei Zhang and Zhao, \{Xin Bin\} and Hong Yang and Min Ni",

year = "2012",

doi = "10.3724/SP.J.1008.2012.001315",

language = "英语",

volume = "33",

pages = "1315--1318",

journal = "Academic Journal of Second Military Medical University",

issn = "0258-879X",

publisher = "Second Military Medical University Press",

number = "12",

}

TY - JOUR

T1 - Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats

AU - Zhang, Wei

AU - Zhao, Xin Bin

AU - Yang, Hong

AU - Ni, Min

PY - 2012

Y1 - 2012

N2 - Objective To determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. Methods SAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). Results Both pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. Conclusion Opening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.

AB - Objective To determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. Methods SAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). Results Both pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. Conclusion Opening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.

KW - Blood pressure variability

KW - Sinoaortic denervated

KW - Vascular smooth muscle

UR - https://www.scopus.com/pages/publications/85108982254

U2 - 10.3724/SP.J.1008.2012.001315

DO - 10.3724/SP.J.1008.2012.001315

M3 - 文章

AN - SCOPUS:85108982254

SN - 0258-879X

VL - 33

SP - 1315

EP - 1318

JO - Academic Journal of Second Military Medical University

JF - Academic Journal of Second Military Medical University

IS - 12

ER -

Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats

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Keywords

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